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Cariology, Restorative Sciences, and Endodontics

Domenica (Nikki) Sweier, DDS, PhD

Domenica Sweier photo

Clinical Associate Professor

Assistant Director, AEGD Program
Cariology, Restorative Sciences, and Endodontics
School of Dentistry, Room 1376-C
University of Michigan
1011 N University
Ann Arbor, MI 48109-1078 
TEL = 734-615-3210
FAX = 734-936-1597
EMAIL = additional contact information |  
                                                 Complete CV

Major Responsbilities:

Course Director: Patient with Special Needs
Course Co-Director: Infection & Immunity
Core Faculty, Comprehensive Care Clinic
Assistant Director, Advanced Education in General Dentistry Program

Dr. Domenica "Nikki" Sweier is a graduate of the University of Michigan School of Dentistry and has a certificate in Hospital Dentistry with a focus on Geriatrics and Special Needs Adults.
She is a Clinical Associate Professor with clinical teaching duties in both the graduate and undergraduate dental clinics and maintains a basic science research component in the Laboratory of Molecular Pathogenesis. Dr. Sweier also lectures to both dental and dental hygiene students in the following courses/topics: caries risk management; medically compromised patients; Oral Facial Function I; restorative dentistry for hygiene; and the Science & Practice of Dentistry in the 21st Century for undergraduate students.


Description of Research Area(s):

Dr. Sweier is involved in basic science research which investigates host parasite interactions in periodontal disease in humans.  This specifically involves examining the host immune response to specific pathogens and what makes some humans more susceptible to this disease than others. She has also recently become involved in clinical research in Geriatric Dentistry involving caries prevention and oral health education among non-dental health care practitioners.


  1. Shelburn CE, Sweier DG, Shelburne PS, Lopatin DE P. gingivalis HtpG Cross-tolerizes Multiple LPS Molecules. J Dent Res 2011; 90 (Spec Iss A): Abstr 287.
  2. Sweier DG, Coopamah M, Lopatin DE, Fenno JC, Shelburne Ce.  Cytokine Modulation by Porphyromonas gingivalis HtpG in Human Monocytic Cells. J Dent Res 2011; 90(Spec Iss A): Abstr 288.
  3. Shelburne CE, Shelburne SP, Sweier DG, Kinney JS, Braun TM, Giannobile WV, Lpatin DE.  Low Levels of anti- P. gingivalis HtpG P18 Predict Peridontal Disease Progression. J Dent Res 2010; 89(Spec IssB): Abstr 3707.
  4. Sweier DG, Shelburne SP, Giannobile WV, Kinney JS, Lopatin DE,  Shelburne CE.  IgG class, but not IgA or IgM, antibodies to peptides of the Porphyromonas gingivalis chaperone HtpG predict health in periodontitis using a fluorescent ELISA.  Clin Vaccine Immunol 2009;16(12):1766-73. [PubMed]
  5. Shelburne CE, Shelburne SP, Dhople VM, Sweier DG, Giannobile WV, Kinney J, Coulter WA, Mullally BH,  Lopatin DE.  Serum Antibodies to Porphyromonas gingivalis.  Chaperone HtpG Predict Health in Periodontitis Susceptible Patients. PLoS ONE 2008;3(4):e1984.doi:10.1371/journal.pone.0001984. [PubMed]
  6. Capone R, Wang HT, Ning Y, Sweier DG, Lopatin DE,  Fenno JC.  Human Serum Antibodies Recognize Treponema denticola Msp and PrtP protease complex proteins.  Oral Micro Immuno 2008;23(2)165-9. [PubMed]
  7. Shelburne CE, Coopamah MD, Sweier DG, An F, Lopatin DE. HtpG, the Porphyromonas gingivalis HSP-90 homologue, induces the chemokine CXCL8 in Human Monocytic and Microvascular Vein Endothelila Cells.  Cellular Microbiology 2007;9(6):1611-1619. [PubMed]
  8. Kozarov E, Sweier DG, Shelburne CE, Progulske-Fox A, Lopatin DE.  Detection of bacterial DNA in atheromatous plaques by qunatitative PCR.  Microbes and Infection  2006;8(3):687-693. [PubMed]
  9. Sweier DG, Shelburne CE, Cameron JC, Lopatin DE.  Localizing antibody-defined epitopes in Porphyromonas gingivalis HtpG recognized by human serum utilizing selective protein expression. Journal of Immunological Methods 2004;285:165-170. [PubMed]
  10. Sweier DG, Combs A, Shelburne CE, Fenno JC, Lopatin DE. Construction and characterization of a Porphyromonas gingivalis htpG disruption mutant. FEMS Microbiology Letters 2003;225(1):101-106.  [PubMed]
  11. Lopatin DE, Combs A, Sweier DG, Fenno JC, Dhamija S. Characterization of the heat-inducible expression and cloning of the HtpG (Hsp90 Homologue) of Porphyromonas gingivalis. Infection & Immunity 2000;68(4):19807.  [PubMed]
  12. Jacobson JG, Renau TE, Nassiri MR, Sweier DG, Breitenbach JM, Townsend LB, et al. Nonnucleoside pyrrolopyrimidines with a unique mechanism of action against human cytomegalovirus.  Antimicrobial Agents and Chemotherapy 1999;43(8):1888-94. [PubMed]




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Updated on 01/02/2014