OHS PhD Faculty

  • Robert Bradley  |  rmbrad@umich.edu
    Neurophysiology of central taste circuits; central integration of taste and salivary functions; functional regeneration of sensory nerves through implanted electrodes.
  • Lucia Cevidanes |   luciacev@umich.edu
    Development of novel open-source software for 3D quantitative analysis and statistical modeling of bone apposition/resorption and positional displacements with growth and/or orthopedic /surgical/pharmacological treatments.  Such open-source methodologies have applications for craniofacial soft and hard tissues, joints, and dental assessments.
  • Daniel Jr. Chiego |   djchiego@umich.edu
    Role of nerves in maintenance and repair of mineralized tissues; neural control of salivation.
  • Brian Clarksonbricla@umich.edu
    Effects of non-collagenous dentin and enamel matrix proteins on dentin and enamel (re)mineralizaton; and the regeneration of dentin and enamel using dental pulp stem cells and ameloblast lineage cells.
  • Nisha D'Silva  |  njdsilva@umich.edu
    Molecular and cellular mechanisms of signaling in normal and malignant keratinocytes.
  • Alexandre DaSilva  |  adasilva@umich.edu
    Neuroplasticity and novel therapeutic approaches and mechanisms in chronic trigeminal pain disorders, including TMD.
  • Stephen Feinberg  |  sefein@umich.edu
    Ex vivo development of a human full-thickness oral mucosal tissue that is suitable for intraoral grafting procedures and for in situ transmucosal delivery of recombinant immunomodulatory proteins.
  • J. Christopher Fenno  |  fenno@umich.edu
    Molecular biology of oral spirochete bacteria; interactions between oral bacteria and host tissues.
  • Margherita Fontana  |  mfontan@umich.edu
    Caries management in children, including risk assessment, dental sealants, oral biofilms as it relates to caries development and/or prevention (and included in this area, therapies that may affect the biofilm, such as xylitol), secondary caries, caries remineralization, and early caries detection. Her work has received funding from the National Institutes of Health, the American Academy of Pediatric Dentistry, the Delta Dental Foundation, and private industry.
  • Renny Franceschi  |  rennyf@umich.edu
    Signals regulating differentiation and function of osteoblasts, and gene therapy approaches for bone regeneration.
  • Jian-Guo Geng |   jgeng@umich.edu
    The Geng Laboratory is focused on how to integrate tissue regeneration with host immunity to reject metastatic cancers. Specifically, the lab is focused on how to boost T-cell antitumor responses in vivo for rejection and vaccination of nonviral cancers.
  • Geoffrey Gerstner  |  geger@umich.edu
    Dr. Gerstner’s research interests include: understanding the proximate (neurophysiological) and ultimate (evolutionary) sources of variation in chewing rate among mammalian species. Methods involve both field- and laboratory-based studies designed to understand how the relative dependence/independence of chewing rate and skull mass has consequences for normal dentoskeletal growth and development and for adaptive capacities of wild mammalian populations. Findings to date suggest that chewing rate may be partially genetically determined, is independent of dentoskeletal size and shape under conditions of relaxed selection pressure, may play a role in dentoskeletal growth and development, and may be a surrogate variable that correlates with the rates of other neural and behavioral processes within and between species. The second research interest deals with studies of chronic trigeminal pain. He is currently working with other investigators on campus using neuroimaging (1H-MRS, fMRI, fcMRI) and psychometric methods to study the neural basis of chronic temporomandibular disorder (TMD) pain. To date, results suggest that chronic TMD symptoms may be modulated by or related to changes in central pain processing. This project is NIH funded.
  • William Giannobile |   wgiannob@umich.edu
    Gene delivery strategies for oral and periodontal tissue engineering, signal transduction mechanisms during oral wound repair, and clinical trials relevant to oral microfluidic diagnostics.
  • Nan Hatch |   nhatch@umich.edu
    My current research activities fall under two primary categories. The first of these is the development development of biologic mediators for control of orthodontic tooth movement and prevention of relapse after orthodontic tooth movement (orthodontic relapse is the tendency for teeth to move back to their original positions upon removal of orthodontic appliances and is an undesirable outcome after correction of a malocclusion through orthodontic treatment). Of greater relevance to the Oral Health Sciences program are my research activities in the areas of bone biology and craniofacial skeletal development. The overall objective of my research is to establish essential molecular mechanisms underlying abnormal craniofacial skeletal development and craniosynostosis. 
  • G. Rex Holland  |  rholland@umich.edu
    Oro-facial nerve injury and the structural basis of pain from teeth.
  • Jan Hu |   janhu@umich.edu
    Characterization of genes and gene products involved in normal and abnormal tooth development.
  • Vesa Kaartinen  |  vesak@umich.edu
    Molecular reasons behind craniofacial and cardiac birth malformations, such as, cleft palate, cleft lip and cardiac valve and septal anomalies; growth factor signaling in normal development in order to understand reasons that often lead to a failure in these particular developmental processes.
  • David Kohn  |  dhkohn@umich.edu
    Biomineralization and biomimetics; focus on biomechanics of mineralized tissues and biomaterials to support replacement/ regeneration of mineralized tissue.
  • Kenichi Kuroda  |  kkuroda@umich.edu
    My research focuses on the design and synthesis of non-toxic antimicrobial polymers by mimicking the properties and functions of natural antimicrobial peptides. This class of polymers is easy to make and inexpensive as compared to peptides and antibiotic drugs, allowing the production of antimicrobial materials on industrial scales.
  • Fei Liu  | feiliu@umich.edu
    Cellular and molecular mechanisms in skeletal, craniofacial development and disease; roles of autophagy in mesenchymal stem/stromal cell and osteoblast functions.
  • Isabelle Lombaert   |  lombaert@umich.edu 
    Lombaert Lab Website
  • Peter Ma  |  mapx@umich.edu
    Bone and periodontal tissue regeneration: (1) stem cells (embryonic and mesenchymal stem cells) and their interactions with biomaterials; (2) spatially and temporally controlled delivery of growth/differentiation factors using nanotechnologies to mediate cell proliferation and differentiation.
  • Laurie McCauley  |  mccauley@umich.edu
    Hormonal controls of bone remodeling at the molecular, cell and tissue level and in particular the therapeutic roles of parathyroid hormones in bone, and their pathophysiologic roles in cancer.
  • Yuji Mishina  |  mishina@umich.edu
    Functions of BMP signaling during bone development/remodeling and craniofacial development, using genetically altered mouse lines to conditionally decrease or increase levels of BMP signaling; models are of interest in understanding the pathogenesis of bone mass related diseases, including osteoporosis and sclerosis.
  • Charlotte Mistretta  |  chmist@umich.edu
    Developmental neurobiology of taste organs, oral sensory ganglia and neural circuits; pattern formation in taste papillae.
  • Jacques Nor |   jenor@umich.edu
    Cellular and molecular mechanisms of angiogenesis; regulation of endothelial cell apoptosis; anti-angiogenic therapies to control the progression and metastasis of oral tumors.
  • Mathilde Peters  |  mcpete@umich.edu
    Cariology; modification of caries risk; (international) clinical studies with emphasis on minimally invasive caries management and bioactive materials.
  • Brian Pierchala  |  pierchal@umich.edu
    Mechanisms of action of neuronal growth factors in the development and maintenance of the peripheral and craniofacial nervous systems.
  • Peter Polverini |   neovas@umich.edu
    Mechanisms of oral carcinogenesis; angiogenesis in oral tumor formation.
  • Helena Ritchie  |  helenar@umich.edu
    Molecular and biochemistry mysteries of the dentin protein phosphoprotein.
  • James Simmer  |  jsimmer@umich.edu
    Genetic and biochemical mechanisms of tooth development, particularly dental enamel formation.
  • Russell Taichman  |  rtaich@umich.edu
    Interactions between bone and hematopoietic cells, bone marrow metastasis, chemokines, growth factors, adhesion molecules, mechanisms of bone metastasis.