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Periodontics and Oral Medicine

Yvonne Kapila, DDS, PhD

 photoProfessor

Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Ave
Ann Arbor, MI 48109-1078
Phone: 734-615-2295
email: ykapila@umich.edu
Recent Publications | Kapila Lab


Education

1997-1998 - Cell Biology, Postdoctorate, Stanford University, Stanford CA
1997 - PhD, Oral Biology, University of California, San Francisco CA
1994 - Certificate, Periodontology, University of California, San Francisco CA
1990 - DDS, BS, Dentistry, University of California, San Francisco CA
1986 - BA, Human Biology, Stanford University, Stanford CA

Professional Experience

2011-present - Professor, Department of Periodontics/Prevention/Geriatrics, University of Michigan
2004-2011 - Associate Professor,  Department of Periodontics/Prevention/Geriatrics, University of Michigan
1999-2004 - Assistant Professor, Department of Stomatology, Division of Periodontology UCSF
1997-1999 - Assistant Adjunct Professor, Department of Stomatology, Division of Periodontology UCS
1994-1997 - Assistant Research, Department of Stomatology, Division of Periodontology UCSF
1993-1994 - Visiting Assistant Research, Department of Stomatology, UCSF
1991-1994 - Dentist in private practice in San Francisco, one half day per week
1991-1993 - Postgraduate Research, Department of Stomatology, Division of Periodontology, UCSF
1983-1986 - Lab Assistant, Stanford University/VA Hospital (Neuropath Lab Dr. Lawrence Eng)

Recent Honors and Awards

2006-present - NIH ODCS Study Section Reviewer-Standing Member
2006 - NIH ODCS Study Section Reviewer- Ad Hoc Member
2000 - UCSF Faculty Development Award
1997 - Winner of the Edward H. Hatton Awards of the American Association for Dental Research
1997 - Winner of the Baliant Orban Research Competition-American Academy of Periodontology

Research Interests

My lab focuses on three main areas of research. One area involves understanding the underlying cell-matrix interactions that govern disease progression in inflammatory diseases such as periodontal tissues. These studies encompass both basic cell and molecular biology studies and patient/translational investigations. Another related area that our lab has recently embarked on relates to expanding our understanding of the mechanisms by which matrix metalloproteinases (MMPs) triggered by inflammatory disease-modulated-matrices may enhance osteoclast activity and diminish osteoblast differentiation. Lastly, the other main area of research in my lab involves understanding the cell-matrix interactions that govern cell survival and invasion/migration of squamous cell carcinomas.

See Kapila Lab

Recent Publications

Kamarajan P, Shin JM, Qian X, Matte B, Zhu JY, Kapila YL. ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC. Cancer Med. 2013 Dec;2(6):793-802.

Abuhussein H, Bashutski JD, Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Kapila Y. The Role of Factors Associated With Apoptosis in Assessing Periodontal Disease Status. J Periodontol. 2013 Dec 22. [Epub ahead of print]

Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer. 2013 Mar;4(3-4):164-71.

Makhoul H, Bashutski J, Halubai S, Dabiri D, Benavides E, Kapila YL. Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis. J Int Acad Periodontol. 2013 Jan;15(1):2-7.

Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila YL. Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. Cancer Med. 2012 Dec;1(3):295-305.

Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A. Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target. Int J Biochem Cell Biol. 2012 Nov;44(11):1852-61.

Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila YL. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer. 2012 Dec 1;118(23):5800-10.

Somashekar BS, Kamarajan P, Danciu T, Kapila YL, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A. Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues. J Proteome Res. 2011 Nov 4;10(11):5232-41.

Scanlon CS, Marchesan JT, Soehren S, Matsuo M, Kapila YL. Capturing the Regenerative Potential of Periodontal Ligament Fibroblasts. J Stem Cells Regen Med. 2011 Jan 1;7(1):54-56.

Alhazzazi TY, Kamarajan P, Verdin E, Kapila YL. SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta. 2011 Aug;1816(1):80-8. Hayami T, Kapila YL, Kapila S. Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3). Matrix Biol. 2011 May;30(4):281-9.

Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila YL. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer. 2011 Apr 15;117(8):1670-8.

Marchesan JT, Scanlon CS, Soehren S, Matsuo M, Kapila YL. Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review. Arch Oral Biol. 2011 Oct;56(10):933-43.

Bunek J, Kamarajan P, Kapila YL. Anoikis mediators in oral squamous cell carcinoma. Oral Dis. 2011 May;17(4):355-61.

Pirih FQ, Michalski MN, Cho SW, Koh AJ, Berry JE, Ghaname E, Kamarajan P, Bonnelye E, Ross CW, Kapila YL, Jurdic P, McCauley LK. Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6. PLoS One. 2010 Oct 27;5(10):e13657.

Kamarajan P, Garcia-Pardo A, D'Silva NJ, Kapila YL. The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion. BMC Cancer. 2010 Jun 25;10:330.

Ghosh A, Chen TC, Kapila YL. Anoikis triggers Mdm2-dependent p53 degradation. Mol Cell Biochem. 2010 Oct;343(1-2):201-9.

Paula-Silva FW, Ghosh A, Arzate H, Kapila S, da Silva LA, Kapila YL. Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1- and ERK-dependent manner. Calcif Tissue Int. 2010 Aug;87(2):144-57.

Ghosh A, Joo NE, Chen TC, Kapila YL. Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells. J Periodontal Res. 2010 Aug;45(4):481-7.

Joseph J, Kapila YL, Hayami T, Kapila S. Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1. Calcif Tissue Int. 2010 Feb;86(2):154-62. Epub 2009 Dec 2. PubMed PMID: 19953231.

Paula-Silva FW, da Silva LA, Kapila YL. Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment. J Endod. 2010 Feb;36(2):231-7. PMID: 20113780.

Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila YL. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell. 2010 Feb;21(3):481-8. Epub 2009 Dec 2. PubMed PMID: 19955213; PubMed Central PMCID: PMC2814792. 

Daniels TE, Kapila YL. Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan;109(1); author reply 4. Epub 2009 Oct 14. PubMed PMID: 19828340.

de Paula-Silva FW, D'Silva NJ, da Silva LA, Kapila YL. High matrix metalloproteinase activity is a hallmark of periapical granulomas. J Endod. 2009 Sep;35(9):1234-42. PubMed PMID: 19720222; PubMed Central PMCID: PMC2736957.

Paula-Silva FW, Ghosh A, Silva LA, Kapila YL. TNF-alpha promotes an odontoblastic phenotype in dental pulp cells. J Dent Res. 2009 Apr;88(4):339-44. PubMed PMID: 19407154.

Xu J, Wang W, Kapila Y, Lotz J, Kapila S. Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells. Stem Cells Dev. 2009 Apr;18(3):487-96. PubMed PMID: 18593336; PubMed Central PMCID: PMC2702120.

Ghosh A, Park JY, Fenno C, Kapila YL. Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death. Infect Immun. 2008 Dec;76(12):5514-23. Epub 2008 Oct 6. PubMed PMID: 18838522; PubMed Central PMCID: PMC2583576.

Hayami T, Kapila YL, Kapila S. MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells. Matrix Biol. 2008 Oct;27(8):682-92. Epub 2008 Aug 5. PubMed PMID: 18755271; PubMed Central PMCID: PMC2683744.

Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila YL. NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation. Cell Death Differ. 2008 May;15(5):899-907. Epub 2008 Feb 22. PubMed PMID: 18292781.

Kamarajan P, Kapila YL. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis. 2007 Dec;12(12):2221-31. PubMed PMID: 17879163.

Hayami T, Zhang Q, Kapila Y, Kapila S. Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression. Bone. 2007 Jan;40(1):93-104. Epub 2006 Aug 24. PubMed PMID: 16934542.

Tafolla E, Wang S, Wong B, Leong J, Kapila YL. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem. 2005 May 20;280(20):19992-9. Epub 2005 Mar 18. PubMed PMID: 15778501.

Dai R, Iwama A, Wang S, Kapila YL. Disease-associated fibronectin matrix fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed. Apoptosis. 2005 May;10(3):503-12. PubMed PMID: 15909113.

Lu H, Jin D, Kapila YL. Application of laser capture microdissection to phage display peptide library screening. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec;98(6):692-7. PubMed PMID: 15583542.

Zhang Y, Lu H, Dazin P, Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J Biol Chem. 2004 Nov 12;279(46):48342-9. Epub 2004 Aug 24. PubMed PMID: 15331608.