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Periodontics and Oral Medicine

Russell Taichman, DMD, DMSc

 photoProfessor of Dentistry and Director of University of Michigan Scholars Program in Dental Leadership

Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Ave
Ann Arbor, MI 48109-1078
734-764-9952
rtaich@umich.edu
 
Recent Publications


Education

1983 - BS, Villanova University
1986 - DMD, University of Pennsylvania
1990 - DMSc, Harvard University
1990 - Certificate in Periodontics, Harvard University
1992 - Post-Doctoral Fellowship, University of Pennsylvania

Academic Appointments and Professional Experience

2005-present - Professor, Department of Periodontics and Oral Medicine
1998-2005 - Associate Professor, Department of Periodontics, Prevention, &Geriatrics, University of Michigan School of Dentistry
1998-present - Consultant; Dental Service, Ann Arbor VA Medical Center
1992-1998 - Assistant Professor, Department of Periodontics, Prevention & Geriatrics, University of Michigan School of Dentistry
1991-1992 - Consultant, Dental Service, Philadelphia VA Medical Center
1990-1992 - Postdoctoral Research Fellow, Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine
1987-1990 - Orthopedic Research Fellow, Department of Orthopedics. Children's Hospital Corp. Boston, MA
1986-1987 - Surgical Research Fellow, Department of Surgery, Brigham and Women's Hospital, Boston MA
1986-1990 - Fellow in Periodontology, Harvard University, School of Dental Medicine

Research Interests

Research in the laboratory of Dr. Russell Taichman focuses on the role of osteoblasts in normal bone marrow function. The laboratory is currently trying to identify the osteoblast-derived factor(s) that support hematopoiesis. Identifying these mechanisms may someday ultimately reduce the morbidity/mortality associated with bone marrow transplants and will likely lead to the identification of novel methods to improve bone engraftment for regenerative therapies. Recent NIDCR grants have allowed the group to dissect the molecular events that mediate cell-to-cell adhesion between osteoblasts and hematopoietic stem cells. Part of the receptor complex that has been uncovered is novel and may be involved in how stem cells return to the marrow during bone marrow transplantation. In a second related project, the group is studying the mechanisms used by tumor cells to metastasize to the bone marrow. It has been found that part of the mechanism relates to products secreted by osteoblasts in the bone marrow that interact with receptors on tumor cells. Currently the focus is on the receptor CXCR4 (an HIV co-receptor). This receptor binds stromal derived factor-1 (SDF-1) which we believe directs the chemotaxis of prostate cancers towards the marrow. In fact, the group has recently demonstrated that blocking CXCR4 resulted in fewer tumors in animals. Recently funded projects include examinations of genetic variability in these genes that regulate tumor progression and metastasis.

Interview with Dr. Russell Taichman - Cancer Stem Cells and the Hematopoietic Stem Cell Niche.

Recent Publications

Havens A, Sun H, Shiozawa Y, Jung Y, Wang J, Mishra A, Jiang Y, O'Neill DW, Krebsbach PH, Rodgerson DO, Taichman RS. Human and Murine Very Small Embryonic-Like (VSEL) Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo. Stem Cells Dev. 2013 Dec 29. [Epub ahead of print] PubMed PMID:24372153.

Forest AE, Taichman RS, Inglehart MR. Dentists' leadership-related perceptions, values, experiences and behavior: Results of a national survey. J Am Dent Assoc. 2013 Dec;144(12):1397-405. PubMed PMID: 24282270.

Kalenderian E, Taichman RS, Skoulas A, Nadershahi N, Victoroff KZ. Developing the next generation of leaders in oral health. J Dent Educ. 2013 Nov;77(11):1508-14. PubMed PMID: 24192416.

Pienta KJ, Robertson BA, Coffey DS, Taichman RS. The cancer diaspora: Metastasis beyond the seed and soil hypothesis. Clin Cancer Res. 2013 Nov1;19(21):5849-55.

Kim JK, Jung Y, Wang J, Joseph J, Mishra A, Hill EE, Krebsbach PH, Pienta KJ, Shiozawa Y, Taichman RS. TBK1 regulates prostate cancer dormancy through mTOR inhibition. Neoplasia. 2013 Sep;15(9):1064-74. PubMed PMID: 24027431

Shiozawa Y, Taichman RS, Keller ET. Detection and isolation of human disseminated tumor cells in the murine bone marrow stem cell niche. Methods Mol Biol. 2013;1035:207-15.

Shiozawa Y, McGee S, Pienta MJ, McGregor N, Jung Y, Yumoto K, Wang J, Berry JE, Pienta KJ, Taichman RS. Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis. J Cell Biochem. 2013 Nov;114(11):2471-8.

Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, Wang J, Jin T, Zhang H, Dai J, Krebsbach PH, Keller ET, Pienta KJ, Taichman RS. Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun. 2013;4:1795.

Taichman RS, Patel LR, Bedenis R, Wang J, Weidner S, Schumann T, Yumoto K, Berry JE, Shiozawa Y, Pienta KJ. GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. PLoS One. 2013 Apr 24;8(4):e61873.

Shiozawa Y, Nie B, Pienta KJ, Morgan TM, Taichman RS. Cancer stem cells and their role in metastasis. Pharmacol Ther. 2013 May;138(2):285-93.

Havens AM, Shiozawa Y, Jung Y, Sun H, Wang J, McGee S, Mishra A, Taichman LS, Danciu T, Jiang Y, Yavanian G, Leary E, Krebsbach PH, Rodgerson D, Taichman RS. Human very small embryonic-like cells generate skeletal structures, in vivo. Stem Cells Dev. 2013 Feb 15;22(4):622-30.

Novince CM, Entezami P, Wilson CG, Wang J, Oh S, Koh AJ, Michalski MN, Sinder BP, Kozloff KM, Taichman RS, McCauley LK. Impact of proteoglycan-4 and parathyroid hormone on articular cartilage. J Orthop Res. 2013 Feb;31(2):183-90.

Yu C, Shiozawa Y, Taichman RS, McCauley LK, Pienta K, Keller E. Prostate cancer and parasitism of the bone hematopoietic stem cell niche. Crit Rev Eukaryot Gene Expr. 2012;22(2):131-48. Review. PubMed PMID: 22856431

Soki FN, Li X, Berry J, Koh A, Sinder BP, Qian X, Kozloff KM, Taichman RS, McCauley LK. The effects of zoledronic acid in the bone and vasculature support of hematopoietic stem cell niches. J Cell Biochem. 2013 Jan;114(1):67-78.

Jung Y, Shiozawa Y, Wang J, McGregor N, Dai J, Park SI, Berry JE, Havens AM, Joseph J, Kim JK, Patel L, Carmeliet P, Daignault S, Keller ET, McCauley LK, Pienta KJ, Taichman RS. Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment. Neoplasia. 2012 May;14(5):429-39. PubMed PMID:22745589.

Sun H, Jung Y, Shiozawa Y, Taichman RS, Krebsbach PH. Erythropoietin modulates the structure of bone morphogenetic protein 2-engineered cranial bone. Tissue Eng Part A. 2012 Oct;18(19-20):2095-105.

Taichman RS, Parkinson JW. Where is leadership training being taught in U.S. dental schools? J Dent Educ. 2012 Jun;76(6):713-20. PubMed PMID: 22659699.

Shiozawa Y, Taichman RS. Getting blood from bone: an emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their niche. Exp Hematol. 2012 Sep;40(9):685-94.

Mishra A, Wang J, Shiozawa Y, McGee S, Kim J, Jung Y, Joseph J, Berry JE, Havens A, Pienta KJ, Taichman RS. Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer. Mol Cancer Res. 2012 Jun;10(6):703-12.

Pedersen EA, Shiozawa Y, Pienta KJ, Taichman RS. The prostate cancer bone marrow niche: more than just 'fertile soil'. Asian J Androl. 2012 May;14(3):423-7.

Shiozawa Y, Taichman RS. Cancer Stem Cells and the Bone Marrow Microenvironment. Bonekey Rep. 2012 Mar 1;2012(1). pii: 48. PubMed PMID:23745167; PubMed Central PMCID: PMC3671623.

Taichman RS, Parkinson JW, Nelson BA, Nordquist B, Ferguson-Young DC, Thompson JF Jr. Program design considerations for leadership training for dental and dental hygiene students. J Dent Educ. 2012 Feb;76(2):192-9. PubMed PMID:22319084.

Taichman RS, Parkinson JW, Nelson BA, Nordquist B, Ferguson-Young DC, Thompson JF Jr. Leadership training for oral health professionals: a call to action. J Dent Educ. 2012 Feb;76(2):185-91. PubMed PMID: 22319083.

Joseph J, Shiozawa Y, Jung Y, Kim JK, Pedersen E, Mishra A, Zalucha JL, Wang J, Keller ET, Pienta KJ, Taichman RS. Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol Cancer Res. 2012 Mar;10(3):282-92.

Pedersen EA, Shiozawa Y, Mishra A, Taichman RS. Structure and function of the solid tumor niche. Front Biosci (Schol Ed). 2012 Jan 1;4:1-15. Review. PubMed PMID: 22202039; PubMed Central PMCID: PMC3594847.

Kim J, Jung Y, Sun H, Joseph J, Mishra A, Shiozawa Y, Wang J, Krebsbach PH, Taichman RS. Erythropoietin mediated bone formation is regulated by mTOR signaling. J Cell Biochem. 2012 Jan;113(1):220-8.

McGee SJ, Havens AM, Shiozawa Y, Jung Y, Taichman RS. Effects of erythropoietin on the bone microenvironment. Growth Factors. 2012 Feb;30(1):22-8.

Koh AJ, Novince CM, Li X, Wang T, Taichman RS, McCauley LK. An irradiation-altered bone marrow microenvironment impacts anabolic actions of PTH. Endocrinology. 2011 Dec;152(12):4525-36.

Patel LR, Camacho DF, Shiozawa Y, Pienta KJ, Taichman RS. Mechanisms of cancer cell metastasis to the bone: a multistep process. Future Oncol. 2011 Nov;7(11):1285-97.

Novince CM, Koh AJ, Michalski MN, Marchesan JT, Wang J, Jung Y, Berry JE, Eber MR, Rosol TJ, Taichman RS, McCauley LK. Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells. Am J Pathol. 2011 Nov;179(5):2431-42.

Mishra A, Shiozawa Y, Pienta KJ, Taichman RS. Homing of cancer cells to the bone. Cancer Microenviron. 2011 Dec;4(3):221-35.

Shiozawa Y, Pienta KJ, Taichman RS. Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors. Clin Cancer Res. 2011 Sep 1;17(17):5553-8.

Barber M, Wiesen R, Arnold S, Taichman RS, Taichman LS. Perceptions of business skill development by graduates of the University of Michigan Dental School. J Dent Educ. 2011 Apr;75(4):505-17. PubMed PMID: 21460271.

Bagramian RA, Taichman RS, McCauley L, Green TG, Inglehart MR. Mentoring of dental and dental hygiene faculty: a case study. J Dent Educ. 2011 Mar;75(3):291-9. PubMed PMID: 21368253.

Jung Y, Shiozawa Y, Wang J, Patel LR, Havens AM, Song J, Krebsbach PH, Roodman GD, Taichman RS. Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche. Exp Hematol. 2011 Feb;39(2):151-166.e1.

Pinsky HM, Taichman RS, Sarment DP. Adaptation of airline crew resource management principles to dentistry. J Am Dent Assoc. 2010 Aug;141(8):1010-8. PubMed PMID: 20675428.

Shiozawa Y, Jung Y, Ziegler AM, Pedersen EA, Wang J, Wang Z, Song J, Wang J, Lee CH, Sud S, Pienta KJ, Krebsbach PH, Taichman RS. Erythropoietin couples hematopoiesis with bone formation. PLoS One. 2010 May 27;5(5):e10853.

Shiozawa Y, Taichman RS. Dysfunctional niches as a root of hematopoietic malignancy. Cell Stem Cell. 2010 May 7;6(5):399-400.

Taichman RS, Wang Z, Shiozawa Y, Jung Y, Song J, Balduino A, Wang J, Patel LR, Havens AM, Kucia M, Ratajczak MZ, Krebsbach PH. Prospective identification and skeletal localization of cells capable of multilineage differentiation in vivo. Stem Cells Dev. 2010 Oct;19(10):1557-70.

Havens AM, Shiozawa Y, Jung Y, Sun H, Wang J, McGee S, Mishra A, Taichman LS, Danciu T, Jiang Y, Yavanian G, Leary E, Krebsbach PH, Rodgerson D, Taichman RS. Human very small embryonic-like cells generate skeletal structures, in vivo. Stem Cells Dev. 2013 Feb 15;22(4):622-30.

Taichman LS, Havens AM, Van Poznak CH. Potential implications of adjuvant endocrine therapy for the oral health of postmenopausal women with breast cancer. Breast Cancer Res Treat. 2013 Jan;137(1):23-32.

Taichman LS, Sohn W, Kolenic G, Sowers M. Depot medroxyprogesterone acetate use and periodontal health in 15- to 44-year-old US females. J Periodontol. 2012 Aug;83(8):1008-17.

Barber M, Wiesen R, Arnold S, Taichman RS, Taichman LS. Perceptions of business skill development by graduates of the University of Michigan Dental School. J Dent Educ. 2011 Apr;75(4):505-17. PubMed PMID: 21460271.

Coplen AE, Klausner CP, Taichman LS. Status of current dental hygiene faculty and perceptions of important qualifications for future faculty. J Dent Hyg. 2011 Winter;85(1):57-66. Epub 2011 Jan 1. PubMed PMID: 21396264.

Shiozawa Y, Pedersen EA, Patel LR, Ziegler AM, Havens AM, Jung Y, Wang J, Zalucha S, Loberg RD, Pienta KJ, Taichman RS. GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche. Neoplasia. 2010 Feb;12(2):116-27. PMID: 20126470.

Song J, Kiel MJ, Wang Z, Wang J, Taichman RS, Morrison SJ, Krebsbach PH.An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood. 2010 Jan 28. [Epub ahead of print] PMID: 20110425.

Wang J, Ying G, Wang J, Jung Y, Lu J, Zhu J, Pienta KJ, Taichman RS. Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer pr ogression. Cancer Res. 2010 Jan 15;70(2):471-80. Epub 2010 Jan 12. PMID: 20068185.

Jung Y, Shiozawa Y, Wang J, Wang J, Wang Z, Pedersen EA, Lee CH, Hall CL, Hogg PJ, Krebsbach PH, Keller ET, Taichman RS. Expression of PGK1 by prostate cancer cells induces bone formation. Mol Cancer Res. 2009 Oct;7(10):1595-604. Epub 2009 Oct 13. PubMed PMID: 19825988.

Taichman RS, Green TG, Polverini PJ. Creation of a scholars program in dental leadership (SPDL) for dental and dental hygiene students. J Dent Educ. 2009 Oct;73(10):1139-43. PubMed PMID: 19805778.

Zieker D, Königsrainer I, Tritschler I, Löffler M, Beckert S, Traub F, Nieselt K, Bühler S, Weller M, Gaedcke J, Taichman RS, Northoff H, Brücher BL, Königsrainer A. Phosphoglycerate kinase 1 a promoting enzyme for peritoneal dissemination in gastric cancer. Int J Cancer. 2009 Aug 17. PubMed PMID: 19688824.

Hsiao AY, Torisawa YS, Tung YC, Sud S, Taichman RS, Pienta KJ, Takayama S. Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials. 2009 Jun;30(16):3020-7. Epub 2009 Mar 21. PubMed PMID: 19304321; PubMed Central PMCID: PMC2675053.

Le TT, Scheller EL, Pinsky HM, Stefanac SJ, Taichman RS. Ability of dental students to deliver oxygen in a medical emergency. J Dent Educ. 2009 Apr;73(4):499-508. PubMed PMID: 19339437.

Wang J, Lu Y, Wang J, Koch AE, Zhang J, Taichman RS. CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway. Cancer Res. 2008 Dec 15;68(24):10367-76. PubMed PMID: 19074906.

Coleman RE, Guise TA, Lipton A, Roodman GD, Berenson JR, Body JJ, Boyce BF, Calvi LM, Hadji P, McCloskey EV, Saad F, Smith MR, Suva LJ, Taichman RS, Vessella RL, Weilbaecher KN. Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference. Clin Cancer Res. 2008 Oct 15;14(20):6387-95. Review. PubMed PMID: 18927277.

Shiozawa Y, Havens AM, Jung Y, Ziegler AM, Pedersen EA, Wang J, Wang J, Lu G, Roodman GD, Loberg RD, Pienta KJ, Taichman RS. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. J Cell Biochem. 2008 Oct 1;105(2):370-80. PubMed PMID: 18636554.

Jung Y, Song J, Shiozawa Y, Wang J, Wang Z, Williams B, Havens A, Schneider A, Ge C, Franceschi RT, McCauley LK, Krebsbach PH, Taichman RS. Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche. Stem Cells. 2008 Aug;26(8):2042-51. Epub 2008 May 22. PubMed PMID: 18499897.

Havens AM, Chiu E, Taba M, Wang J, Shiozawa Y, Jung Y, Taichman LS, D'Silva NJ, Gopalakrishnan R, Wang C, Giannobile WV, Taichman RS. Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. J Periodontol. 2008 May;79(5):845-53. PubMed PMID: 18454663; PubMed Central PMCID: PMC2582372.

Shiozawa Y, Havens AM, Pienta KJ, Taichman RS. The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites. Leukemia. 2008 May;22(5):941-50. Epub 2008 Feb 28. Review. PubMed PMID: 18305549.

Lu Y, Wang J, Xu Y, Koch AE, Cai Z, Chen X, Galson DL, Taichman RS, Zhang J. CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. Mol Cancer Res. 2008 Apr;6(4):546-54. Epub 2008 Mar 14. PubMed PMID: 18344492.

Havens AM, Pedersen EA, Shiozawa Y, Ying C, Jung Y, Sun Y, Neeley C, Wang J, Mehra R, Keller ET, McCauley LK, Loberg RD, Pienta KJ, Taichman RS. An in vivo mouse model for human prostate cancer metastasis. Neoplasia. 2008 Apr;10(4):371-80. PubMed PMID: 18392141; PubMed Central PMCID: PMC2288546.

Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R, Taichman RS. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem. 2008 Feb 15;283(7):4283-94. Epub 2007 Dec 5. PubMed PMID: 18057003.

Sun YX, Pedersen EA, Shiozawa Y, Havens AM, Jung Y, Wang J, Pienta KJ, Taichman RS. CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12. Clin Exp Metastasis. 2008;25(7):765-76. Epub 2008 Jun 18. PubMed PMID: 18563594.

Keller ET, Dai J, Escara-Wilke J, Hall CL, Ignatoski K, Taichman RS, Keller J. New trends in the treatment of bone metastasis. J Cell Biochem. 2007 Dec 1;102(5):1095-102. Review. PubMed PMID: 17955492.

Taichman RS, Loberg RD, Mehra R, Pienta KJ. The evolving biology and treatment of prostate cancer. J Clin Invest. 2007 Sep;117(9):2351-61. PubMed PMID: 17786228; PubMed Central PMCID: PMC1952634.

Jung Y, Wang J, Song J, Shiozawa Y, Wang J, Havens A, Wang Z, Sun YX, Emerson SG, Krebsbach PH, Taichman RS. Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation. Blood. 2007 Jul 1;110(1):82-90. Epub 2007 Mar 14. PubMed PMID: 17360942; PubMed Central PMCID: PMC1896130.

Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood. 2007 May 1;109(9):3706-12. Epub 2007 Jan 16. Erratum in: Blood. 2007 Jul 1;110(1):17. PubMed PMID: 17227831.

Saraiva MC, Taichman RS, Braun T, Nriagu J, Eklund SA, Burt BA. Lead exposure and periodontitis in US adults. J Periodontal Res. 2007 Feb;42(1):45-52. PubMed PMID: 17214639.

Wang J, Wang J, Dai J, Jung Y, Wei CL, Wang Y, Havens AM, Hogg PJ, Keller ET, Pienta KJ, Nor JE, Wang CY, Taichman RS. A glycolytic mechanism regulating an angiogenic switch in prostate cancer. Cancer Res. 2007 Jan 1;67(1):149-59. PubMed PMID: 17210694.

Sun YX, Fang M, Wang J, Cooper CR, Pienta KJ, Taichman RS. Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells. Prostate. 2007 Jan 1;67(1):61-73. PubMed PMID: 17034033.