Skip to content Skip to navigation

Periodontics and Oral Medicine

Rogerio Castilho, DDS, MS, PhD

Rogerio Castilho PhotoAssistant Professor

Division of Oral Pathology/Medicine/Radiology
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave Rm 3323B
Ann Arbor, MI 48109-1078
Phone 734-647-2150 | rcastilh@umich.edu

  - Recent Publications


Education

2003 - 2009 - Post-Doctorate, Oral Pharyngeal Cancer Branch at the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA
2001 - 2003 - PhD, Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
1999 - 2000 - Master of Science (MS) in Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
1999 - 1999 - Certificate in Oral Pathology, Sao Leopoldo Mandic, Campinas, SP, Brazil
1992 - 1995 - DDS, Pontific Catholic University of Campinas, Campinas, Brazil

Honors and Awards

2003 - 2006 - Fellowship award for post-doctoral training, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH).
2001 - 2003 - Fellowship award for PhD education, CAPES (Coordination of Training of Higher Education Graduate).
2001 - Edward H. Hatton, IADR Brazilian Division (co-author, First Prize), Brazilian Society of Dentistry for research (SBPqO).
1999 - 2001 - Fellowship award for Master of Science education, CAPES (Coordination of Training of Higher Education Graduate).

Academic Appointments and Professional Experience

2010 - present - Assistant Professor, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
1999 - 2003 - Surgical and Experimental Pathology training and service, University of Sao Paulo, Sao Paulo, Brazil.
1997 - 1999 - Dental Surgeon, Private Practice, Santa Barbara D’Oeste, Brazil.
1996 - 1999 - Dental Surgeon, Private Practice, Campinas, Brazil.

Research Interests

  • Epithelial Stem Cells
  • Oncogene-Induced-Senescence (OIS)
  • Molecular Networks of Head and Neck Cancer
  • Wound-Healing and Tissue Remodeling
  • Aging

Recent Publications

Luciana O. Almeida, Aline C. Abrahao, Luciana K. Rosselli-Murai, Fernanda S. Giudice, Chiara Zagni, Andreia M. Leopoldino, Cristiane H. Squarize, Rogerio M. Castilho. NFκB mediates cisplatin resistance through histone modifications in head and neck squamous cell carcinoma (HNSCC). FEBS Open Bio 2014; vol.4: 96-104.

Ana Carolina A. Pellicioli, Manoela D. Martins, Caroline S. Dillenburg, Márcia M. Marques, Cristiane H. Squarize, Rogerio M. Castilho. Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mTOR signaling pathway. Journal Biomedical Optics. 2014-Accepted.

Rosselli-Murai LK, Almeida LO, Zagni C, Galindo-Moreno P, Padial-Molina M, Volk SL, Murai MJ, Rios HF, Squarize CH, Castilho RM. Periostin Responds to Mechanical Stress and Tension by Activating the MTOR Signaling Pathway. PLoS One. 2013 Dec 13;8(12):e83580.

Warner KA, Adams A, Bernardi L, Nor C, Finkel KA, Zhang Z, McLean SA, Helman J, Wolf GT, Divi V, Queimado L, Kaye FJ, Castilho RM, Nör JE. Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral Oncol. 2013 Nov;49(11):1059-66.

Castilho RM, Squarize CH, Gutkind JS. Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. Oral Dis. 2013 Sep;19(6):551-8.

Martins MD, Castilho RM . Histones: Controlling a Tumor Signaling Circuitry. J Carcinogene Mutagene. 2013 July 29.

Sales K, Giudice F, Castilho R, Salles F, Squarize C, Abrahao A, Pinto D Jr. Cyclin D1-induced proliferation is independent of beta-catenin in Head and Neck Cancer. Oral Dis. 2013 May 2. PubMed PMID: 23730900.

Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS. PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia. 2013 May;15(5):461-71. PubMed PMID: 23633918.

Giudice FS, Pinto DS Jr, Nör JE, Squarize CH, Castilho RM. Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One. 2013;8(3):e58672. Epub 2013 Mar 20. PubMed PMID: 23527004.

Castilho RM, Squarize CH, Gutkind JS. Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. Oral Dis. 2013 Sep;19(6):551-8. Epub 2013 Feb 4. PubMed PMID: 23379329.

Abrahao AC, Castilho RM, Squarize CH, Molinolo AA, dos Santos-Pinto D Jr, Gutkind JS. A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncol. 2010 Dec;46(12):880-7. Epub 2010 Oct 14. PubMed PMID: 20951077.

Castilho RM, Squarize CH, Bugge TH, Gutkind JS. Rac1 Is Required for Epithelial Stem Cell Function during Dermal and Oral Mucosal Wound Healing but not for Tissue Homeostasis in Mice. PLoS One. 2010 (in press).

Squarize CH, Castilho RM, Bugge TH, Gutkind JS. Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models. PLoS One. 2010 (in press).

Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt- induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 2009 Sep; 4;5(3):279- 89. PubMed PMID: 19733540.

Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. Dysregulated Molecular Networks in Head and Neck Carcinogenesis. Oral Oncol. 2009 Apr-May;45(4-5):324-34. Pubmed PMID: 18805044.

Squarize CH, Castilho RM, Gutkind JS. Chemoprevention and Treatment of Experimental Cowden’s Disease by mTOR Inhibition with Rapamycin. Cancer Res. 2008 Sep 1;68(17):7066-72. PubMed PMID: 18757421.

Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 2007 Aug 10;317(5839):803-6. PubMed PMID: 17690294.

Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 2;26(35):5078-85. PubMed PMID: 17334398.

Squarize CH, Castilho RM, Sriuranpong V, Pinto DS Jr, Gutkind JS. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006 Sep; 8(9):733-46. PubMed PMID: 16984731.

Basile JR, Castilho RM, Williams VP, Gutkind JS. Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9017-22. Epub 2006 Jun 5. PubMed PMID: 16754882; PubMed Central PMCID: PMC1482558.

Castilho RM, Squarize CH, Nunes FD, Pinto DS Jr. Osteolipoma: a rare lesion in the oral cavity. Br Jf Oral Maxillofac Surg. 2004 Aug; 42(4): 363-4. PubMed PMID: 15225961.

Squarize CH, Castilho RM, Pinto DS Jr. Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system. J Oral Pathol Med. 2002 Aug; 31(7): 379-84. PubMed PMID: 12224530.

Book Chapters

Rogerio M. Castilho and Silvio J. Gutkind. The Wnt β-catenin Signaling Circuitry in Head and Neck Cancer. Molecular Targets of HNC. Edited by Drs Golemis and Burtness and Erica Golemis. Springer Science, 2014. In press.

Squarize CH, Castilho RM, Leopoldino AM. Drug Target Validation. Current Methods in Medicinal Chemistry and Biological Physics Vol. 2. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 167-186, 2008.

Squarize CH, Castilho RM. Emerging animal models. In Current Methods in Medicinal Chemistry and Biological Physics. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 207-226, 2007.