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Periodontics and Oral Medicine

Renny T. Franceschi, PhD

 photoProfessor of Dentistry, School of Dentistry
Professor of Biological Chemistry, Medical School
Professor of Biomedical Engineering, College of Engineering

 
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Ave Rm 3397
Ann Arbor, MI 48109-1078
734-763-7381 rennyf@umich.edu
Recent Publications


Education

BA, University of Vermont
PhD, Purdue University
Postdoctoral, University of Wisconsin

Recent Honors and Awards

2008 - Biological Mineralization Award, International Association for Dental Research
2006 - Chair of the Skeletal Biology, Structure and Regeneration Study Section at the Center for Scientific Review at NIH
2004, 1998 - Mentor to American Society for Bone and Mineral Research Young Investigator Awardees, Dr. G. Xiao and C. Ge
2001 - President, IADR Mineralized Tissues Group

Research Interests

The Franceschi laboratory is studying signals regulating the formation and functioning of osteoblasts, cells that produce and mineralize the extracellular matrix of bone, and is applying this knowledge to regenerate mineralized tissues for eventual clinical use. Research is focused on mechanisms controlling osteoblast-specific gene expression with particular emphasis on the roles of bone-associated transcription factors, hormones/growth factors, cell:extracellular matrix interactions, and mechanical force in this process. Endocrine/juxtacrine factors under study include several bone morphogenetic proteins (BMPs), fibroblast-derived growth factors and parathyroid hormone.

My research group is part of the University of Michigan Musculoskeletal Research Center and the Center for Craniofacial Regeneration, an interactive group of researchers in the Schools of Medicine, Dentistry and Engineering having the common goal of conducting basic and applied research directed toward treating diseases of mineralized tissues.

Recent Publications

McElderry JD, Zhu P, Mroue KH, Xu J, Pavan B, Fang M, Zhao G, McNerny E, Kohn DH, Franceschi RT, Holl MM, Tecklenburg MM, Ramamoorthy A, Morris MD. Crystallinity and compositional changes in carbonated apatites: Evidence from (31)P solid-state NMR, Raman, and AFM analysis. J Solid State Chem. 2013 Oct;206.

Wilson CG, Martín-Saavedra FM, Vilaboa N, Franceschi RT. Advanced BMP gene therapies for temporal and spatial control of bone regeneration. J Dent Res. 2013 May;92(5):409-17.

Fabiilli ML, Wilson CG, Padilla F, Martín-Saavedra FM, Fowlkes JB, Franceschi RT. Acoustic droplet-hydrogel composites for spatial and temporal control of growth factor delivery and scaffold stiffness. Acta Biomater. 2013 Jul;9(7):7399-409.

Martín-Saavedra FM, Wilson CG, Voellmy R, Vilaboa N, Franceschi RT. Spatiotemporal control of vascular endothelial growth factor expression using a heat-shock-activated, rapamycin-dependent gene switch. Hum Gene Ther Methods. 2013 Jun;24(3):160-70.

McElderry JD, Zhao G, Khmaladze A, Wilson CG, Franceschi RT, Morris MD. Tracking circadian rhythms of bone mineral deposition in murine alvarial organ cultures. J Bone Miner Res. 2013 Aug;28(8):1846-54.

Wang W, Olson D, Liang G, Franceschi RT, Li C, Wang B, Wang SS, Yang S. Collagen XXIV (Col24α1) promotes osteoblastic differentiation and mineralization through TGF-β/Smads signaling pathway. Int J Biol Sci. 2012;8(10):1310-22.

Park ES, Park J, Franceschi RT, Jo M. The role for runt related transcription factor 2 (RUNX2) as a transcriptional repressor in luteinizing granulosa cells. Mol Cell Endocrinol. 2012 Oct 15;362(1-2):165-75.

Li Y, Ge C, Long JP, Begun DL, Rodriguez JA, Goldstein SA, Franceschi RT. Biomechanical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor. J Bone Miner Res. 2012 Jun;27(6):1263-74.

Ge C, Yang Q, Zhao G, Yu H, Kirkwood KL, Franceschi RT. Interactions between extracellular signal-regulated kinase 1/2 and p38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity. J Bone Miner Res. 2012 Mar;27(3):538-51.

Danciu TE, Li Y, Koh A, Xiao G, McCauley LK, Franceschi RT. The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts. J Cell Biochem. 2012 Jan;113(1):70-9.

Kwon TG, Zhao X, Yang Q, Li Y, Ge C, Zhao G, Franceschi RT. Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J Cell Biochem. 2011 Dec;112(12):3582-93.

Jang WG, Kim EJ, Bae IH, Lee KN, Kim YD, Kim DK, Kim SH, Lee CH, Franceschi RT, Choi HS, Koh JT. Metformin induces osteoblast ifferentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2. Bone. 2011 Apr 1;48(4):885-gma93.

Zhang Y, Deng X, Scheller EL, Kwon TG, Lahann J, Franceschi RT, Krebsbach PH. The effects of Runx2 immobilization on poly (varepsilon-caprolactone) on osteoblast differentiation of bone marrow stromal cells in vitro. Biomaterials. 2010 Feb 1. [Epub ahead of print] PMID: 20129661.

Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Kwon TG, Lai Y, Zhang J, Patrene K, Hankenson K, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One. 2009 Oct 23;4(10):e7583. PubMed PMID: 19851510.

Ge C, Xiao G, Jiang D, Yang Q, Hatch NE, Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009 Sep 30. [Epub ahead of print] PubMed PMID: 19801668.

Jeong BC, Lee YS, Bae IH, Lee CH, Shin HI, Ha HJ, Franceschi RT, Choi HS, Koh JT. The Orphan Nuclear Receptor SHP is a Positive Regulator of Osteoblastic Bone Formation. J Bone Miner Res. 2009 Jul 13. [Epub ahead of print] PubMed PMID: 19594294.

Li Y, Ge C, Franceschi RT. Differentiation-Dependent Association of Phosphorylated Extracellular Signal-Regulated Kinase with the Chromatin of Osteoblast-Related Genes. J Bone Miner Res. 2009 Jul 6. [Epub ahead of print] PubMed PMID: 19580458.

Jeong BC, Lee YS, Park YY, Bae IH, Kim DK, Koo SH, Choi HR, Kim SH, Franceschi RT, Koh JT, Choi HS. The orphan nuclear receptor estrogen receptor-related receptor gamma negatively regulates BMP2-induced osteoblast differentiation and bone formation. J Biol Chem. 2009 May 22;284(21):14211-8. Epub 2009 Mar 26. PubMed PMID: 19324883; PubMed Central PMCID: PMC2682869.

Suttamanatwong S, Jensen ED, Schilling J, Franceschi RT, Carlson AE, Mansky KC, Gopalakrishnan R. Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone. J Cell Biochem. 2009 May 15;107(2):284-92. PubMed PMID: 19306294.

Hatch NE, Li Y, Franceschi RT. FGF2 stimulation of the pyrophosphate-generating enzyme, PC-1, in pre-osteoblast cells is mediated by RUNX2. J Bone Miner Res. 2009 Apr;24(4):652-62. PubMed PMID: 19049325; PubMed Central PMCID: PMC2659512.

Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Cells Tissues Organs. 2009;189(1-4):144-52. Epub 2008 Aug 27. PubMed PMID: 18728356.

Hatch NE, Franceschi RT. Osteoblast differentiation stage-specific expression of the pyrophosphate-generating enzyme PC-1. Cells Tissues Organs. 2009;189(1-4):65-9. Epub 2008 Aug 13. PubMed PMID: 18698132.

Hatch NE, Franceschi RT. FGF2 induced expression of the pyrophosphate generating enzyme, PC-1, is mediated by Runx2 and Msx2. J Musculoskelet Neuronal Interact. 2008 Oct-Dec;8(4):318-20. PubMed PMID: 19147956

Koh JT, Zhao Z, Wang Z, Lewis IS, Krebsbach PH, Franceschi RT. Combinatorial gene therapy with BMP2/7 enhances cranial bone regeneration. J Dent Res. 2008 Sep;87(9):845-9. PubMed PMID: 18719211; PubMed Central PMCID: PMC2593032.

Jung Y, Song J, Shiozawa Y, Wang J, Wang Z, Williams B, Havens A, Schneider A, Ge C, Franceschi RT, McCauley LK, Krebsbach PH, Taichman RS. Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche. Stem Cells. 2008 Aug;26(8):2042-51. Epub 2008 May 22. PubMed PMID: 18499897.

Yu S, Franceschi RT, Luo M, Zhang X, Jiang D, Lai Y, Jiang Y, Zhang J, Xiao G. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology. 2008 Apr;149(4):1960-8. Epub 2008 Jan 10. PubMed PMID: 18187540; PubMed Central PMCID: PMC2276723.

Roca H, Franceschi RT. Analysis of transcription factor interactions in osteoblasts using competitive chromatin immunoprecipitation. Nucleic Acids Res. 2008 Mar;36(5):1723-30. Epub 2008 Feb 7. PubMed PMID: 18263612; PubMed Central PMCID: PMC2275161.

Franceschi RT, Ge C. Gene delivery by adenoviruses. Methods Mol Biol. 2008;455:137-47. PubMed PMID: 18463816.

Zhao Z, Wang Z, Ge C, Krebsbach P, Franceschi RT. Healing cranial defects with AdRunx2-transduced marrow stromal cells. J Dent Res. 2007 Dec;86(12):1207-11. PubMed PMID: 18037657.

Franceschi RT, Ge C, Xiao G, Roca H, Jiang D. Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 2007 Nov;1116:196-207. Review. PubMed PMID: 18083928.

Suttamanatwong S, Franceschi RT, Carlson AE, Gopalakrishnan R. Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways. J Cell Biochem. 2007 Oct 1;102(2):496-505. PubMed PMID: 17407158.

Ge C, Xiao G, Jiang D, Franceschi RT. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 2007 Feb 26;176(5):709-18. PubMed PMID: 17325210; PubMed Central PMCID: PMC2064027.

Koh JT, Ge C, Zhao M, Wang Z, Krebsbach PH, Zhao Z, Franceschi RT. Use of a stringent dimerizer-regulated gene expression system for controlled BMP2 delivery. Mol Ther. 2006 Nov;14(5):684-91. Epub 2006 Aug 14. PubMed PMID: 16905364.

Phimphilai M, Zhao Z, Boules H, Roca H, Franceschi RT. BMP signaling is required for RUNX2-dependent induction of the osteoblast phenotype. J Bone Miner Res. 2006 Apr;21(4):637-46. Epub 2006 Apr 5. PubMed PMID: 16598384; PubMed Central PMCID: PMC2435171.

Hakki SS, Wang D, Franceschi RT, Somerman MJ. Bone sialoprotein gene transfer to periodontal ligament cells may not be sufficient to promote mineralization in vitro or in vivo. J Periodontol. 2006 Feb;77(2):167-73. PubMed PMID: 16460240.