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Periodontics and Oral Medicine

Peter Polverini, DDS, DMSc

 photoProfessor of Oral and Maxillofacial Pathology 

Division of Oral Pathology/Medicine/Radiology
Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Ave
Ann Arbor, MI 48109-1078
neovas@umich.edu
 


Profile

Dr. Polverini is a professor in the Department of Periodontics and Oral Medicine, Division of Oral Pathology/Medicine/Radiology. He is board certified in Oral and Maxillofacial Pathology and a pathologist with the Oral and Maxillofacial Pathology Biopsy Service at the U-M School of Dentistry.

Recent Publications

Polverini PJ. U-M School of Dentistry: transitions. J Mich Dent Assoc. 2013 Sep;95(9):54, 56-9.

Wang Y, Ning Y, Alam GN, Jankowski BM, Dong Z, Nör JE, Polverini PJ. Amino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway. Neoplasia. 2013 Aug;15(8):989-97.

Aksu MN, Polverini PJ. UDM, U-M dental school deans respond to 'change' editorial. J Mich Dent Assoc. 2013 Feb;95(2):11.

Polverini PJ. U-M School of Dentistry: synergy in action. J Mich Dent Assoc. 2012 Sep;94(9):64-7.

D'Souza RN, Ebersole JL, Fox CH, Polverini PJ, Scannapieco FA. How practicing dentists can shape dental research: The American Association for Dental Research's vision for the future. J Am Dent Assoc. 2012 Oct;143(10):1069-71.

Wang Y, Alam GN, Ning Y, Visioli F, Dong Z, Nör JE, Polverini PJ. The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. Cancer Res. 2012 Oct 15;72(20):5396-406.

Polverini PJ. A curriculum for the new dental practitioner: preparing dentists for a prospective oral health care environment. Am J Public Health. 2012 Feb;102(2):e1-3.

Polverini PJ. University of Michigan School of Dentistry: engagement and connections. J Mich Dent Assoc. 2011 Sep;93(9):34-7.

Tarquinio SB, Zhang Z, Neiva KG, Polverini PJ, Nör JE. Endothelial cell Bcl-2 and lymph node metastasis in patients with oral squamous cell carcinoma. J Oral Pathol Med. 2012 Feb;41(2):124-30.

Taichman RS, Green TG, Polverini PJ. Creation of a scholars program in dental leadership (SPDL) for dental and dental hygiene students. J Dent Educ. 2009 Oct;73(10):1139-43. PubMed PMID: 19805778.

Kumar P, Ning Y, Polverini PJ. Endothelial cells expressing Bcl-2 promotes tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion. Lab Invest. 2008 Jul;88(7):740-9. Epub 2008 May 19. PubMed PMID: 18490895.

Kumar P, Gao Q, Ning Y, Wang Z, Krebsbach PH, Polverini PJ. Arsenic trioxide enhances the therapeutic efficacy of radiation treatment of oral squamous carcinoma while protecting bone. Mol Cancer Ther. 2008 Jul;7(7):2060-9. PubMed PMID: 18645016.

Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, Polverini PJ, Mooney DJ. Engineering tumors with 3D scaffolds. Nat Methods. 2007 Oct;4(10):855-60. Epub 2007 Sep 2. PubMed PMID: 17767164.

Dong Z, Neiva KG, Jin T, Zhang Z, Hall DE, Mooney DJ, Polverini PJ, Nör JE. Quantification of human angiogenesis in immunodeficient mice using a photon counting-based method. Biotechniques. 2007 Jul;43(1):73-7. PubMed PMID: 17695255.

Kumar P, Coltas IK, Kumar B, Chepeha DB, Bradford CR, Polverini PJ. Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release. Cancer Res. 2007 Feb 1;67(3):1193-202. PubMed PMID: 17283155.

Hong GK, Kumar P, Wang L, Damania B, Gulley ML, Delecluse HJ, Polverini PJ, Kenney SC. Epstein-Barr virus lytic infection is required for efficient production of the angiogenesis factor vascular endothelial growth factor in lymphoblastoid cell lines. J Virol. 2005 Nov;79(22):13984-92. PubMed PMID: 16254334; PubMed Central PMCID: PMC1280197.

Addison CL, Nör JE, Zhao H, Linn SA, Polverini PJ, Delaney CE. The response of VEGF-stimulated endothelial cells to angiostatic molecules is substrate-dependent. BMC Cell Biol. 2005 Oct 31;6:38. PubMed PMID: 16262896; PubMed Central PMCID: PMC1291360.

Zeng Q, Li S, Chepeha DB, Giordano TJ, Li J, Zhang H, Polverini PJ, Nor J, Kitajewski J, Wang CY. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell. 2005 Jul;8(1):13-23. PubMed PMID: 16023595.

Karl E, Warner K, Zeitlin B, Kaneko T, Wurtzel L, Jin T, Chang J, Wang S, Wang CY, Strieter RM, Nunez G, Polverini PJ, Nör JE. Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines. Cancer Res. 2005 Jun 15;65(12):5063-9. PubMed PMID: 15958549.

Kumar P, Miller AI, Polverini PJ. p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway. J Biol Chem. 2004 Oct 8;279(41):43352-60. Epub 2004 Aug 2. PubMed PMID: 15292252.

Nissen NN, Gamelli RL, Polverini PJ, DiPietro LA. Differential angiogenic and proliferative activity of surgical and burn wound fluids. J Trauma. 2003 Jun;54(6):1205-10; discussion 1211. PubMed PMID: 12813345.

Kumar P, Amin MA, Harlow LA, Polverini PJ, Koch AE. Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis. Blood. 2003 May 15;101(10):3960-8. Epub 2003 Jan 9. PubMed PMID: 12522014.

Kaigler D, Krebsbach PH, Polverini PJ, Mooney DJ. Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells. Tissue Eng. 2003 Feb;9(1):95-103. PubMed PMID: 12625958.

D'Silva NJ, Kurago Z, Polverini PJ, Hanks CT, Paulino AF. Malignant melanoma of the oral mucosa in a 17-year-old adolescent girl. Arch Pathol Lab Med. 2002 Sep;126(9):1110-3. PubMed PMID: 12204064.

Polverini PJ. Angiogenesis in health and disease: insights into basic mechanisms and therapeutic opportunities. J Dent Educ. 2002 Aug;66(8):962-75. Review. PubMed PMID: 12214844.

Peters MC, Polverini PJ, Mooney DJ. Engineering vascular networks in porous polymer matrices. J Biomed Mater Res. 2002 Jun 15;60(4):668-78. PubMed PMID: 11948526.