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Periodontics and Oral Medicine

Laurie K. McCauley, DDS, MS, PhD

Dean
University of Michigan School of Dentistry

The William K. and Mary Anne Najjar Professor
Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1101 N. University Rm #3305
Ann Arbor, MI 48109-1078
734-763-2105   mccauley@umich.edu

  - Recent Publications
  - McCauley Lab


Education

1980 - BS, Education, The Ohio State University
1985 - DDS, The Ohio State University
1988 - MS, Dentistry, The Ohio State University
1991 - PhD, Veterinary Pathobiology, The Ohio State University

Honors and Awards

2011 - Basic Research in Biological Mineralization Award, International Association for Dental Research
2010 - American Dental Education Association (ADEA) William J. Gies Award
2008-2011 - National Institutes of Health (NIH) National Advisory Dental & Craniofacial Research Council Member
2008 - Elected Fellow, American Association for the Advancement of Science
2007-2012 - Associate Editor, Journal of Bone and Mineral Research
2007-2010 - Council member, American Society for Bone and Mineral Research
2006-2009 - Editorial Board, Oral Diseases
2004-2009 - Editorial Board, Journal of Bone and Mineral Research
2002-2007 - Editorial Board, Calcified Tissue International

Academic Appointments and Professional Experience

1984-1985 - Student Teaching Assistant, College of Dentistry, The Ohio State University
1985-1988 - Graduate Teaching Assistant, Department of Periodontology, College of Dentistry, The Ohio State University 1988-1991 - Private practice limited to Periodontics, Marysville, Ohio
1988-1991 - Graduate Research Fellow, Department of Periodontology, College of Dentistry, The Ohio State University
1988-1991 - Graduate Research Fellow, Department of Veterinary Pathobiology, The Ohio State University
1992-1996 - Assistant Professor, Department of Periodontics/Prevention/Geriatrics, University of Michigan
1996-2001 - Associate Professor, Department of Periodontics and Oral Medicine, University of Michigan
1996-2002 - Director, Center for Biorestoration of Oral Health
1992-present - Private practice limited to Periodontics, Dental Faculty Associates, University of Michigan
1998-1999 - Visiting Scientist, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Strasbourg France, Hosted by Professor and Director, Pierre Chambon
2001-present - Associate Professor, Department of Pathology, Medical School, University of Michigan
2001-present - Professor, Department of Periodontics and Oral Medicine (formerly Periodontics/Prevention/Geriatrics), University of Michigan, Ann Arbor, MI
2002-2012 - Chair, Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI
2002-present - William K. and Mary Anne Najjar Professor of Periodontics
2005-2006 - Visiting Scientist, Ecole Normale Supérieure, Lyon France, Hosted by Professor Pierre Jurdic
2013-present - Dean, School of Dentistry, University of Michigan, Ann Arbor, MI

Research Interests

  • Hormonal controls of bone remodeling
  • Anabolic actions of parathyroid hormone (PTH), parathyroid hormone-related protein (PTHrP) and their dependence on the PTH-1 receptor and AP-1 transcription factors to evoke their anabolic actions
  • Impact and therapeutic potential of PTH in craniofacial osseous wound healing
  • The role of PTHrP and the bone marrow microenvironment in the pathophysiology associated with skeletal metastasis
  • Interactions of hematopoietic cells and PTH/PTHrP actions in the bone microenvironment

McCauley Lab

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Recent Publications

Cho SW, Soki FN, Koh AJ, Eber M, Entezami P, Park SI, van Rooijen N, McCauley LK. Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone. PNAS: 111: 1545-50, 2014. PMID 24406853, PMCID PMC3910564

McCauley LK, Dalli J, Koh AJ, Chiang N, Serhan CN. Parathyroid hormone (PTH) facilitates macrophage efferocytosis in bone marrow via pro-resolving mediators resolvin D1 and resolvin D2. Journal of Immunology: In press, 2014.

Simmons J, Elshafae S, Keller E, McCauley LK, Rosol TJ. Review of animal models of prostate cancer bone metastasis. Veterinary Sciences: In press, 2014. Novince CM, Entezami P, Wilson CG, Wang J, Koh AJ, Michalski MN, Sinder BP, Kozloff KM, Taichman RS, McCauley LK. The impact of proteoglycan-4 and parathyroid hormone on articular cartilage degeneration. Journal of Orthopaedic Research: 31:183-90, 2013. PMID 22898906

Cho SW, Pirih FQ, Michalski M, Eber M, Ritchie K, Sinder B, Oh S, Lee J, Kozloff K, Danciu T, Wronski T, McCauley LK. Soluble interleukin-6 receptor signaling is a mediator of hematopoietic and skeletal actions of parathyroid hormone. Journal of Biological Chemistry: 288:6814-25, 2013. PMID 23297399, PMCID PMC3591592

Kuroshima S, Kozloff K, McCauley LK, Yamashita J. Intraoral PTH injections promote tooth extraction socket healing in rats. Journal of Dental Research: 92:553-559, 2013. PMID:23611925, PMCID: PMC3654759

Ding X, Park SI, McCauley LK, Wang CY. Signaling between TGF-beta and Transcription factor SNAI2 Represses Expression of microRNA miR-203 to Promote Epithelial-Mesenchymal Transition and Tumor Metastasis. Journal of Biological Chemistry: 288:10241-53, 2013. PMID 23447531

Kuroshima S, Entezami P, McCauley LK, Yamashita J. Early effects of parathyroid hormone on bisphosphonate/steroid-associated compromised osseous wound healing. Osteoporosis International: In press, 2013. PMID 24301537

Zhang H, Yu C, Dai J, Keller JM, Hua A, Sottnik JL, Shelley G, Hall CL, Park SI, Yao Z, Zhang J, McCauley LK, Keller ET. Parathyroid hormone-related protein inhibits DKK1 expression through c-Jun-mediated inhibition of β-Catenin activation of the DKK1 promoter in prostate cancer. Oncogene:1-14, 2013. PMID 23752183

Jiang Y, Dai J, Zhang H, Sottnik JL, Keller JM, Escott KJ, Sanganee HJ, Yao Z, McCauley LK, Keller ET. Activation of the Wnt pathway through use of AR79, a glycogen synthase kinase 3β inhibitor, promotes prostate cancer growth in soft tissue and bone. Mol Cancer Res: 11:1597-610, 2013. PMID 24088787

Park SI, Lee C, Sadler WD, Koh AJ, Soki FN, Cho SW, Daignault SD, McCauley LK. Parathyroid hormone-related protein supports prostate cancer growth through a CD11b+Gr1+ cell-mediated feedback loop. Cancer Research: 73: 6574-83, 2013. PMID: 24072746

Cho SW, McCauley LK. Parathyroid hormone: A dynamic regulator of bone, immune, and hematopoietic cells. In Osteoimmunology: Interactions of the Immune and Skeletal Systems. Editor: Yongwon Choi, pp 57-72, 2013.

Jordon E, Davis S, Rakes P, McCauley LK, Bashutski J. Vitamin D and dental health. In:Handbook of Vitamin D in Human Health: Prevention, treatment and toxicity. Editor: Ronald Ross Watson, pp 355-372, 2013.

Novince CM, Entezami P, Wilson CG, Wang J, Koh AJ, Michalski MN, Sinder BP, Kozloff KM, Taichman RS, McCauley LK. The impact of proteoglycan-4 and parathyroid hormone on articular cartilage degeneration. Journal of Orthopaedic Research: 31:183-90, 2013. PMID,22898906

Soki FN*, Li X*, Berry J, Koh AJ, Sinder BP, Qian X, Kozloff KM, Taichman RS, McCauley LK. The effects of zoledronic acid in the bone and vasculature support of hematopoietic stem cell niches. Journal of Cellular Biochemistry: 114(1):67-78, 2013. *equal contributions. PMID 22833499

Park SI, McCauley LK. Nuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cells. Endocrine Related Cancer: 19(3):243-54, 2012. PMID 22291434

Jung Y, Shiozawa Y, Wang J, McGregor N, Dai J, Park SI, Berry JE, Havens AM, Joseph J, Kim JK, Patel L, Carmeliet P, Daignault S, Keller ET, McCauley LK, Pienta KJ, Taichman RS. Prevalence of prostate cancer metastases following intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment. Neoplasia: 14:429-439, 2012.

Park SI, Liao J, Berry J, Li X, Koh A, Michalski M, Eber M, Soki F, Sadler W, Sud S, Tisdelle S,  Daignault SD, Nemeth J,  Snyder L, Wronski T, Pienta K, McCauley LK. Cyclophosphamide creates a responsive microenvironment for prostate cancer skeletal metastasis.Cancer Research: 72:2522-2532, 2012. Press release: http://ns.umich.edu/new/multimedia/videos/20392-fertilizing-bone-marrow-helps-answer-why-some-cancers-spread-to-bones

McCauley LK, Martin TJ. Twenty-five years of PTHrP progress from cancer hormone to multifunctional cytokine. Invited Perspective, Journal of Bone and Mineral Research: 27:1231-9, 2012. PMID:22549910

Soki FN, Park SI, McCauley LK. The multi-faceted actions of parathyroid hormone related protein in skeletal metastasis.  Invited review, Future Oncology: 8:803-817, 2012. PMID 22830401

Yu C, Shiozawa Y, Taichman RS, McCauley LK, Pienta KJ, Keller ET. Prostate cancer and parasitism of the bone hematopoietic stem cell niche. Critical Reviews in Eukaryotic Gene Expression: 22:131-148 2012, PMID 22856431.

Yamashita J, McCauley LK. Antiresorptives and osteonecrosis of the jaw. Journal of Evidence Based Dental Practice: 12(3 Suppl):233-47, 2012, PMID:23040351

Chan HL, McCauley LK.  Parathyroid hormone application for craniofacial regeneration. Journal of Dental Research: 92(1):18-25, 2012, PMID:23071071

Danciu TE, Li Y, Koh AJ, Xiao G, McCauley LK, Franceschi RT.  The basic helix loop helix transcription factor twist1 is a novel regulator of ATF4 in osteoblasts. Journal of Cellular Biochemistry: 113:70-79, 2012. PMID: 21866569

Novince CM, Michalski MN,  Sinder BP,Entezami P,  Koh AJ, Eber MJ, Pettway GJ,  Rosol TJ,  Wronski TJ,   Kozloff KM, McCauley LK. Proteoglycan-4: a dynamic regulator of skeletogenesis and PTH skeletal anabolism.  Journal of Bone and Mineral Research:  27:11-25, 2012. PMID 21932346. Video Abstract: http://www.youtube.com/watch?v=e3wtxvDuUu4

Bashutski JD, Kinney J,  Benavides E, Maitra S,  Braun T,  Giannobile WV,  McCauley LK,  Eber RM. Systemic teriparatide administration promotes osseous regeneration of an intrabony defect: A Case Report. Clinical Advances in Periodontics: 2:66-71, 2012.

Li X, Koh AJ, Soki F, Park S, Pienta K, McCauley LK.  Inhibitory effects of megakaryocytes in prostate cancer skeletal metastasis. Journal of Bone and Mineral Research: 26:125-134, 2011 PMID: 20684002.

Thudi NK, Shu ST, Martin CK, Lanigan LG, Nadella MVP, Van Bokhoven A, Werbeck JL, Simmons JK, Murahari S, Kisseberth WC, Breen M, Williams C, Chen C, McCauley LK, Keller ET, Rosol TJ. Development of a brain metastatic canine prostate cancer cell line. Prostate: 71:615-625, 2011.

Li X, Liao J, Park SI, Koh AJ, Sadler WD,Pienta KJ, Rosol TJ, McCauley LK. Drugs Which Inhibit Osteoclast Function Suppress Tumor Growth through Calcium Reduction in Bone. Bone: 48:1354-1361, 2011. PMID: 21419883

Bashutski JD, Eber R, Kinney J, Benavides E, Maitra S, Braun TM, Giannobile WV, McCauley LK. The impact of vitamin D status on periodontal surgery outcomes.  Journal of Dental Research: 09:1007-1012,  2011. PMID: 21555774

Motyl KJ, McCauley LK, McCabe LR. Amelioration of Type I Diabetes-induced Osteoporosis by Parathyroid Hormone is Associated with Improved Osteoblast Survival. Journal of Cellular Physiology: 227:1326-1334, 2012. PMID: 21604269

Weilbaecher KN, Guise TA, McCauley LK.  Cancer to bone: a fatal attraction (Invited review): Nature Reviews Cancer: 11:411-25. PMID: 21593787

Novince CM, Koh AJ, Michalski MN, Marchesan JT, Wang J, Jung Y, Berry JE, Eber MR, Rosol TJ, Taichman RT,   McCauley LK. Proteoglycan-4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells.  American Journal of Pathology: 179:2431-2442, 2011. PMID:21939632.

Koh AJ, Novince CM, Li X, Wang T, Taichman RT, McCauley LK.  An Altered Murine Bone Marrow Microenvironment Impacts Anabolic Actions of PTH. Endocrinology, 152(12):4525-36, 2011. PMID: 22045660

McLean K, Gong Y, Choi Y, Deng N, Yang K, Bai S, Cabreara L, Keller E, McCauley L, Cho K, Buckanovich R. Human Ovarian Carcinoma Associated MSC Regulate Cancer Stem Cells and Tumorigenesis via Altered BMP Production. Journal of Clinical Investigation: 121:3206-3219, 2011. PMID: 21737876

Park SI, Soki FN, McCauley LK. Roles of bone marrow cells in skeletal metastases: No longer bystanders. Cancer Microenvironment: 4:237-246, 2011. PMID: 21809058

Toribio RE,  Brown H,  Novince C, Marlow B, Hernan K, Lanigan L, Hildreth B, Werbeck J, Shu S, Lorch G, Carlton M, Foley J, Bokaya B,   McCauley LK, Rosol TJ. The mid-region, nuclear localization sequence and C-terminus of PTHrP regulate skeletal development, hematopoiesis and survival in mice. FASEB Journal, 24:1947-57, 2010. PMID: 20145205

Wang Z, McCauley LK. Osteoclasts and odontoclasts: signaling pathways to development and disease. Oral Diseases: 17:129-142, 2011, PMID: 20659257.

Thudi NK, Martin CK, Murahari S, Shu SS, Lanigan LG, Werbeck JL, Keller ET, McCauley LK, Pinzones JJ, Rosol TJ. Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases.  Prostate: On-Line October, 2010, PMID: 20957670

Yamashita J, McCauley LK, Van Poznak C.  Updates on Osteonecrosis of the Jaw. Current Opinion in Supportive & Palliative Care: 4(3):200-6,2010, PMID: 20657284.

Yamashita J, Yang DY, Koi A,  McCauley LK.  Effect of zoledronic acid on bone marrow and oral wound healing in rats.  Clinical Cancer Research, 17:1405-1414,2011, PMID: 21149614.

Bagramian RA, Taichman RS, McCauley LK, Green TG, Inglehart MR. Mentoring of dental and dental hygiene faculty: A case study. Journal of Dental Education: In press, 2011.

Pirih F, Michalski M, Koh A, Berry J, Ghaname E, Kamarajan P, Bonnelye E, Ross C, Kapila Y, Jurdic P, McCauley LK. The impact of parathyroid hormone on cells of the hematopoietic lineage: in vivo and ex vivo studies. PloS One, Oct 27;5(10):e13657,2010, PMID: 21048959.

McCauley LK. C-Maf and you won’t see fat. Journal of Clinical Investigation: 120:3440-2, 2010, PMID: 20877008.

Bashutski JD, Eber R, Kinney J, Benavides E, Maitra S, Braun TM, Giannobile WV, McCauley LK. Teriparatide and osseous regeneration in the oral cavity. New England Journal of Medicine: Vol 363: 2396-2405, 2010, PMID: 20950166.

Novince C, Ward B, McCauley LK.  Osteonecrosis of the Jaw: An update and review of recommendations.

Cells, Tissues, Organs: 189(1-4):275-83, 2009. PMID: 18765930

Li X, Loberg R, Liao J, Ying C, Snyder L, Pienta KJ, McCauley LK. A Destructive Cascade Mediated by CCL2 Facilitates Prostate Cancer Growth in Bone. Cancer Research, 69:1685-92, 2009.  PMID: 19176388

Chang J, Wang Z, Tang E, Fan Z, McCauley LK, Franceschi R, Guan K, Krebsbach PH, Wang CY. Inhibition of osteoblast functions by IKK/NF-kB in osteoporosis. Nature Medicine: 15:682-9, 2009. PMID: 19448637.

 

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