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Periodontics and Oral Medicine

Cristiane Squarize, DDS, MS, PhD

Cristiane Squarize PhotoAssistant Professor

Division of Oral Pathology/Medicine/Radiology
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
1011 N. University Ave Rm #3210
Ann Arbor, MI 48109-1078
734-615-3406   |  csquariz@umich.edu
Recent Publications


Education

2003 - 2009 - Post-Doctorate, Oral Pharyngeal Cancer Branch (OPCB) at the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), Bethesda, MD, USA
2005 - PhD, Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
2003 - MS, Oral Pathology, University of Sao Paulo, Sao Paulo, Brazil
1995 - DDS, Pontific Catholic University of Campinas, Campinas, Brazil

Honors and Awards

2003 - 2005 - Fellowship award for post-doctoral training, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH)
2003 - Fellowship award for PhD education, FAPESP (Foundation for the support of research from the State of Sao Paulo)
2002 - Unilever Travel Award, International Association of Dental Research (IADR), 80th Meeting of the International Association for Dental Research/AADR/CADR
2001 - 2003 - Fellowship award for Master of Science education, FAPESP (Foundation for the support of research from the State of Sao Paulo)
2001 - Edward H Hatton, IADR Brazilian Division - (First Prize) - Brazilian Society of Dentistry for research (SBPqO)

Academic Appointments and Professional Experience

2010 - present - Assistant Professor, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
2001 - 2003 – Surgical and Experimental Pathology training and service, University of Sao Paulo, Sao Paulo, Brazil
1996 - 2001 - Dental Surgeon, Proprietor, Private Practice, Campinas, Brazil

Research Interests

  • Head and Neck Cancers
  • Tumor Suppressors
  • Stem Cells
  • Wound-Healing and Tissue Regeneration
  • Pathology

Recent Publications

Rosselli-Murai LK, Almeida LO, Zagni C, Galindo-Moreno P, Padial-Molina M, Volk SL, Murai MJ, Rios HF, Squarize CH, Castilho RM. Periostin Responds to Mechanical Stress and Tension by Activating the MTOR Signaling Pathway. PLoS One. 2013 Dec 13;8(12):e83580.

Wagner VP, Meurer L, Martins MA, Danilevicz CK, Magnusson AS, Marques MM, Filho MS, Squarize CH, Martins MD. Influence of different energy densities of laser phototherapy on oral wound healing. J Biomed Opt. 2013 Dec 1;18(12):128002.

Giudice FS and Squarize CH. The Determinants of Head and Neck Cancer: Unmasking the PI3K Pathway Mutations. Journal of Carcinogenesis and Mutagenesis, 2013 (accepted).

Sales K, Giudice F, Castilho R, Salles F, Squarize C, Abrahao A, Pinto D Jr. Cyclin D1-induced proliferation is independent of beta-catenin in Head and Neck Cancer. Oral Dis. 2013 PMID: 23730900.

Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS. PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia. 2013 May;15(5):461-71.

Giudice FS, Pinto DS Jr, Nör JE, Squarize CH, Castilho RM. Inhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancer. PLoS One. 2013;8(3):e58672.

Castilho RM, Squarize CH, Gutkind JS. Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. Oral Dis. 2013 Sep;19(6):551-8. doi: 10.1111/odi.12070. Epub 2013 Feb 4. PMID: 2337932.

Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Sobral LM, Uyemura SA, Tajara EH, Silvio Gutkind J, Curti C. SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncol. 2012 Jun 25. PMID: 22739068.

Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Polizello AC, Uyemura SA, Tajara EH, Gutkind JS, Curti C. Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling. Mol Cell Biochem. 2012 Apr;363(1-2):65-74. PMID: 22143534.

Abrahao A.C., Castilho R.M., Squarize C.H., Molinolo A.A., Pinto D.S.P., Gutkind J. S.. A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncology 46(12):880-7, 2010. PMID: 20951077.

Squarize CH, Castilho RM, Bugge TH, Gutkind JS. Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One. 2010 May 13;5(5):e10643. PMID: 20498714.

Castilho RM, Squarize CH, Leelahavanichkul K, Zheng Y, Bugge T, Gutkind JS. Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLoS One. 2010 May 6;5(5):e10503. PMID: 20463891.

Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind JS. mTOR mediates Wnt- induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 2009 Sep; 4;5(3):279- 89. PubMed PMID: 19733540.

Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. Dysregulated Molecular Networks in Head and Neck Carcinogenesis. Oral Oncol. 2009 Apr-May;45(4-5):324-34. Pubmed PMID: 18805044.

Squarize CH, Castilho RM, Gutkind JS. Chemoprevention and Treatment of Experimental Cowden’s Disease by mTOR Inhibition with Rapamycin. Cancer Res. 2008 Sep 1;68(17):7066-72. PubMed PMID: 18757421.

Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind JS. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 2;26(35):5078-85. PubMed PMID: 17334398.

Squarize CH, Castilho RM, Sriuranpong V, Pinto DS Jr, Gutkind JS. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006 Sep; 8(9): 733-46. PubMed PMID: 16984731.

Castilho RM, Squarize CH, Nunes FD, Pinto DS Jr. Osteolipoma: a rare lesion in the oral cavity. The British Journal of Oral & Maxillofacial Surgery. 2004 Aug; 42(4): 363-4. PubMed PMID: 15225961.

Squarize CH, Castilho RM, Pinto DS Jr. Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system. Journal of Oral Pathology & Medicine. 2002 Aug; 31(7): 379-84. PubMed PMID: 12224530.

Book Chapters

Squarize CH, Castilho RM, Leopoldino AM. Drug Target Validation. Current Methods in Medicinal Chemistry and Biological Physics Vol. 2. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 167-186, 2008.

Squarize CH, Castilho RM. Emerging animal models. In Current Methods in Medicinal Chemistry and Biological Physics. Edited by Carlton A Taft, Carlos HTP Silva. Research Signpost 207-226, 2007.