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Cariology, Restorative Sciences, and Endodontics

Tatiana Botero, DDS, MS

Tatiana Botero photoClinical Associate Professor

Department of Cariology, Restorative Sciences and Endodontics
School of Dentistry, Room 1376-D
The University of Michigan
1011 N University Ave
Ann Arbor, MI 48109-1078
TEL = 734-936-2526
FAX = 734-936-1597
EMAIL = | additional contact information | CV

Major Responsibilities:

Core Faculty Member in All Graduate and Undergraduate Programs
Course Director

Dr. Tatiana M. Botero received her Dental Degree (DDS, 1987) from CES University in Medellin (Colombia), Specialty training in Endodontics (MS, 1995) at Pontificia Universidad Javeriana in Bogota (Colombia) and the Advanced Specialty Certificate in Endodontics from University of Michigan (2005).

Dr. Botero was a clinical assistant professor and had her private practice in Colombia (1989-2000) and joined to U of M since 2001.

Presently she is full time Clinical Associate Professor and teaches Endodontics to graduate and undergraduate students. Her practice is limited to Endodontics at DFA clinic and her research interest is in caries-induced dental pulp angiogenesis and regenerative Endodontics.

Description of Research Area(s):

Dr. Botero is involved in studying the angiogenic responses in the dental pulp tissues caused by dental caries.  Some topics as Caries-induced angiogenesis of the dental pulp in human teeth.  LPS-induced signaling during VEGF expression.  Anti-angiogenic therapy on the dental pulp (animal model) and MTA effects on odontoblastic differentiation of apical papilla stem cells are the main focus of her research.


  1. Rosa V, Botero TM, Nor JE. Regenerative endodontics in light of the stem cell paradigm. International Dental Journal. 2011 August;61(supp 1):23-28.
  2. Zealand CM, Briskie DM, Botero TM, Boynton JR, Hu JC. Comparing gray mineral trioxide aggregate and diluted formocresol in pulpotomized human primary molars. Pediatr Dent. 2010 Sep-Oct; 32(5):393-399. [PubMed]
  3. Botero TM, Son JS, Vodopyanov D, Hasegawa M, Shelburne CE, Nör JE. MAPK signaling is required for LPS-induced VEGF in pulp stem cells. J Dent Res 2010 Mar; 89(3):264-269.
  4. Soden RI, Botero TM, Hanks CT, Nör JE. Angiogenic signaling triggered by cariogenic bacteria in pulp cells. J Dent Res 2009 Sep;88(9): 835-840.
  5. Mullane EM, Dong Z, Sedgley CM, Hu JC, Botero TM, Holland GR, Nör JE. Effects of VEGF and FGF2 on the revascularization of severed human dental pulps. J Dent Res 2008;87(12):1144-1148.
  6. Botero TM, Shelburne CE, Holland GR, Hanks CT, Nör JE. TLR4 mediates LPS-induced VEGF expression in odontoblast. J Endod 2006;32(10):951-955. [PubMed]
  7. Melegari KK, Botero TM, Holland GR. Prostaglandin E production and viability of cells cultured in contact with freshly mixed endodontic materials. Int Endod J 2006;39(5):357-362. [PubMed]
  8. Mantellini MG, Botero TM, Yaman P, Dennison JB, Hanks CT, Nör JE. Adhesive resin and the hydrophilic monomer HEMA induce VEGF expression on dental pulp cells and macrophages. Dent Materials 2006;22(5):434-440. [PubMed]
  9. Moghaddame-Jafari S, Mantellini MG, Botero TM, McDonald NJ, Nör JE. Effect of ProRoot MTA on pulp cell apoptosis and proliferation In Vitro. J Endod 2005;31(5):387-391. [PubMed]
  10. Hernandez EP, Botero TM, Mantellini MG, McDonald NJ, Nör JE.  Effect of ProRoot®  MTA mixed with chlorehexidine on apoptosis and cell cycle of fibroblasts and macrophages in vitro*. Int Endod J 2005;38(2):137-143. [PubMed]
  11. Mantellini MG, Botero TM, Yaman P, Dennison JB, Hanks CT, Nör JE. Adhesive resin induces apoptosis and cell cycle arrest of pulp cells. J Dent Res 2003;82:592-596.[PubMed]
  12. Botero TM, Mantellini MG, Song W, Hanks CT, Nör JE. Effect of lipolysaccharide on endothelial growth factor expression in mouse pulp cells and macrophages. Eur J Oral Sci  2003;111:228-234. [PubMed]

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Updated on 01/02/2014