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Cariology, Restorative Sciences, and Endodontics

Helena Ritchie, MS, PhD

Helena Ritchie photographAssociate Professor

Cariology, Restorative Sciences and Endodontics
School of Dentistry, Room 2303
University of Michigan
1011 N University Ave
Ann Arbor, MI 48109-1078
TEL = 734-763-3746
FAX = 734-936-1597
EMAIL = helenar@umich.edu
Additional information | Complete CV  | Research

 


 

Major Responsibilities:

Course Director, DENTXXX, IMS Module 1
Course Director, DENTED606, Mineralized Tissues

Special Distinctions:

Undergraduate Research Opportunity Program Faculty Recognition Award (2007)

Description of Research:

Dr. Ritchie is focused on studying two major dentin noncollagenous proteins -- dentin sialoprotein (DSP) and physophporyn (PP) -- whose appearance is coupled to the conversion of uncalcified predentin to calcified dentin.  The work encompassess following four DSP-PP related areas: (1) regulation and function of rat dentin sialoprotein and phosphophoryn, (2) tissue engineering to test whether DSP and PP proteins can serve as biomimetic molecules in promoting dentin regeneration, (3) DSP-PP gene expression in non-mineralized tissues such as bone, kidney and salivary glands during organogenesis, and (4) DSP-PP precursor processing studies.

 

Publications:

  1. Yang RT, Lim GL, Dong ZH, Lee AR, Yee CT, Fuller RS, Ritchie HH.  The efficiency of Dentin sialoprotein-Phosphophoryn processing by mutations both flanking and distrant from the clevage site. J Biol Chem 2013 February 22; 288(8): 6024-6033.
  2. Ritchie HH, Yee CT, Tang X, Fuller RS.  DSP-PP Precursor Protein Cleavage by Toll related-1 protein and Bone Morphogenetic Protein-1.  PLoS ONE 2012 July; 7(7):341110.
  3. Tang XN, Zhu YQ, Marcelo CL, Ritchie HH.  Expression of mineralized tissue associated proteins: Dentin sialoprotein and phosphophoryn in rodent hair follicles. J Dermatological Science 2011 Nov; 64(2): 92-98.
  4. li LF, Zhu YQ, Jiang L, Peng WW, Ritchie HH.  Hypoxia promotes mineralization of human dental pulp cells.  J Endod 2011 April; 37(6): 799-802.

 

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updated 01/02/2014