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Cariology, Restorative Sciences, and Endodontics

Daniel Chiego Jr., MS, PhD

Dan Chiego Photograph

Associate Professor

Cariology, Restorative Sciences, and Endodontics
School of Dentistry, Room 1360-B
University of Michigan Ave
1011 N University
Ann Arbor, MI 48109-1078
TEL = 734-763-4258
FAX = 734-936-1597
EMAIL = djchiego@umich.edu | Complete CV
 


Major Responsibilities:

Course Director, Student Research Program
Course Director, DENT511, Development Biology of the Dentition
Course Director, DH219, Oral Histology and Embryology
Course Director, ENDO656, Pulpal Biology
Course Director, DENT651-751-851, Dental Student Research II (Elective)


Special Distinctions:

President, Ann Arbor Local Chapter of AADR School of Dentistry, Student Research Advocate
 

Research Interests:

His research interests are the role of nerves in maintenance and repair of mineralized tissues including osteoblasts/cytes of bone and odontoblasts in the dental pulp.  Dr. Chiego uses various techniques to demonstrate up and down regulation of genes and proteins associated with mineralized tissue formation. 

Currently he is using immunohistochemistry and electrophysiology to demonstrate afferent and efferent neural, central and peripheral pathways with salivation.
 

Research Areas:

Dr. Chiego is involved with innervation of the pulp.  This is of particular interest because of the variety of its roles in development, growth, pain, inflammation/immunity and repair.  These roles occur in most peripheral tissues but in the dental pulp they are concentrated in a well defined anatomical area.  Pain and the response to injury are of considerable clinical interest for understanding pulpal injury and improvements in pulpal repair may offer a simpler and less expensive option than either root canal therapy or tooth extraction.  Dr. Chiego is also studying central mechanisms of salivation and how specific autonomic nerves innervating the nucleus of the solitary tract and the inferior salivatory nucleus interact within the brainstem.  He is also involved in comparing the temporal sequence of gene expression (inflammatory mediators and growth factors) found in periapical granulomas and cysts using gene arrays, histopathology and digital radiography which will progress to an animal study to resolve these lesions using nanotechnology.

Dr. Chiego is also collaborating with several investigators at Wayne State Medical School to study the unfolded protein response in head and neck cancer patients using immunohistochemistry to determine expression of several genes associated with primary squamous carcinoma in humans.
 

Abstracts:

  1. J. MILLER1, A. BROWNELL1D. CHIEGO Jr.2, S. BECHLER3, L. JACKSON3, D. SHERMAN4, R.J. KAUFMAN5, M. CALLAGHAN1, and A. FRIBLEY1Borrelidin Induces OSCC Cell Death via the Unfolded Protein Response.  , 1Pediatrics, Wayne State University, Detroit, MI, 2School of Dentistry, University of Michigan, Ann Arbor, MI, 3Lyman Briggs, Michigan State University, East Lansing, MI,4University of Michigan, Ann Arbor, MI, 5Neuroscience, Aging, and Stem Cell Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA
  2. KIM JK1, CHIEGO DJ Jr 1, BAKER J1 NOR J1 HILL E2  IKKbi conjugated dendrimer modulates inflammatory response of dental pulp cells.  Tissue Injury and Pulp Regeneration, Geneva, Switzerland, 2010:9.
  3. MTor Plays a Pivotal Role in Odontoblast Differentitation.  KIM JK1, CHIEGO DJ Jr 1, BAKER J1 NOR J1 HILL E21University of Michigan, Ann Arbor, MI, 2Universityof Michigan, Ann Arbor, MI. IADR Barcelona 2010
  4. Chiego DJ Jr1 Hill E E 2 Cordell KG 3, 4  Jin TMcDonald NJIKKβ Inhibitor Increased Healing Rate of Periapical Lesions in Rats. University of Michigan, School of Dentistry. Depts. of Cariology, Restorative Sciences and Endodontics1, Biologic and Materials Sciences2, Periodontics and Oral Medicine and University of Michigan Medical School, Department of Pathology4, Molecular Biology Core5. Tissue Injury and Pulp Regeneration, Geneva, Switzerland, 2010:23.
  5. Chiego DJ Jr1 Hill E E 2 Cordell KG 3, 4  Jin TMcDonald NJ1.A Novel Method for Targeted Treatment of Periapical Lesions  University of Michigan School of Dentistry Depts. of Cariology, Restorative Sciences and Endodontics1, Biologic and Materials Sciences2, Periodontics and Oral Medicine and University of Michigan Medical School, Department of Pathology4, Molecular Biology Core5.  IADR Barcelona 2010:1388.
  6. Chiego DJ Jr., E.E. Hill, K. Cordell, N.J. McDonald.  Novel drug delivery system for the treatment of periapical granulomas.  Presented at the Michigan Clinical Research Symposium:  Bridging the gap between research and practice.  University of Michigan, October 2008.
  7. Kim, M, Suwabe, T., Chiego DJ Jr, Bradley, R.M..  Excitatory Postsynaptic Activity of the Rat Inferior Salivatory Nucleus Neurons.  Presented at Annual Meeting for Association for Chemoreception Sciences, Sarasota, FL. 2006;166
  8. M.Kim; Chiego DJ Jr, R.M.Bradley Characterization of the gusto-salivary reflex: iontropic glutamate receptor expression in preganglionic neurons of the rat inferior Salivatory nucleus.  Presented at Society for Neuroscience Annual Meeting, Washington, DC. 2005;1456.

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Updated on 01/02/2014