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Biologic and Materials Sciences and Division of Prosthodontics

Ma Lab: Polymeric Biomaterials and Tissue Engineering Lab

Selected Recent Journal Articles and Book Chapters (2009 - 2014)


  1. P.X. Ma, Biomimetic Materials for Tissue Engineering, Advanced Drug Delivery Reviews, 60(2): 184-198 (2008). (Featured as a Fast Breaking Paper in ScienceWatch, August 2009).
  2. JX Zhang and PX Ma. Polymeric Core-Shell Assemblies Mediated by Holst-Guest Interactions: Versatile Nanocarriers for Drug Delivery, Angewandte Chemie International Edition. 48(5): 964-968 (2009).
  3. IO Smith, XH Liu, LA Smith and PX Ma. Nano-structured polymer scaffolds for tissue engineering and regenerative medicine, Wiley Interdisciplinary Reviews: Nanomedicine, 1: 226-236 (2009).
  4. YG Ko and PX Ma. Surface-grafting of phosphates onto a polymer for potential biomimetic functionalization of biomaterials. Journal of Colloid and Interface Science. 330(1), 77-83 (2009).
  5. LA Smith, X Liu, P Wang, J Hu and PX Ma. Enhancing Osteogenic Differentiation of Mouse Embryonic Stem Cells by Nanofibers, Tissue Engineering. 15(7): 1855-1864 (2009).
  6. LA Smith, X Liu, J Hu, and PX Ma. The Influence of Three Dimensional Nanofibrous Scaffolds on the Osteogenic Differentiation of Embryonic Stem Cells. Biomaterials. 30(13): 2516-2522 (2009).
  7. X Liu, LA Smith, J Hu, and PX Ma. Biomimetic nano-fibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials. 30(12): 2252–2258 (2009).
  8. K.M. Woo, V.J. Chen, H.J. Kim, H.M. Jung, T.I. Kim, H.I. Shin, J.H. Baek, H.M. Ryoo, and PX Ma. Comparative evaluation of nano-fibrous scaffolding for bone regeneration in critical size calvarial defects. Tissue Engineering, 15(8): 2155-62 (2009).
  9. P Wang, J Hu, PX Ma. The Engineering of Patient-specific, Anatomically Shaped, Digits, Biomaterials, 30(14): 2735-2740 (2009).
  10. X Liu and PX Ma, Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds, Biomaterials, 30(25): 4094-4103 (2009).
  11. J Hu, K Feng, X Liu, PX Ma, Chondrogenic and osteogenic differentiations of human bone marrow-derived mesenchymal stem cells on a nanofibrous scaffold with designed pore network, Biomaterials, 30(28): 5061-5067 (2009)
  12. G Wei and PX Ma. Partially nanofibrous architecture of 3D tissue engineering scaffolds. Biomaterials. 30(32): 6426-6434 (2009).
  13. X Liu, IO Smith and PX Ma. Biomimetic nanophase materials for tissue engineering (Chapter 14), In: Rena Bizios, David A. Puleo (Editors), Biological Interactions on Materials Surfaces: Understanding and Controlling Protein, Cell, and Tissue Responses, Springer, New York, NY, pp283-296 (2009).
  14. AP Loeffler and PX Ma, Chapter 3. Bioinspired Nanomaterials for Tissue Engineering, in Challa Kumar (Ed),Nanomaterials for the Life Sciences Vol.7: Biomimetic and Bioinspired Nanomaterials, Wiley-VCH Verlag GmbH & Co., KGaA, Weinheim. Pp 89-123 (2010).
  15. Q Jin, PX Ma, and WV Giannobile. Platelet-derived Growth Factor Delivery via Nanofibrous Scaffolds for Soft Tissue Engineering. Advances in Wound Care. 1:375-381 (2010).
  16. X Liu and PX Ma, The nanofibrous architecture of poly(L-lactic acid)-based functional copolymers. Biomaterials. 31(2):259-269 (2010).
  17. H Tian, S Bharadwaj, Y Liu, PX Ma and A Atala. Myogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells on a 3D Nanofibrous Scaffold for Bladder Tissue Engineering, Biomaterials. 31(5): 870-7 (2010).
  18. H Sun, K Feng, J Hu, S Soker, A Atala and PX Ma. Osteogenic Differentiation of Human Amniotic Fluid–derived Stem Cells Induced by Bone Morphogenetic Protein-7 and Enhanced by Nanofibrous Scaffolds. Biomaterials. 31(6): 1133-1139 (2010).
  19. JX Zhang, K Feng, M Cuddihy, NA Kotov and PX Ma, Spontaneous formation of temperature-responsive assemblies by molecular recognition of a b-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide). Soft Matter. 6: 610-617 (2010).
  20. JX Zhang, H Sun and PX Ma, Host-guest Interaction Mediated Multifunctional Polymeric Nano-assemblies for Simultaneous Drug and Gene Delivery. ACS Nano. 4(2): 1049-1059 (2010).
  21. IO Smith and PX Ma. Cell and Biomolecule Delivery for Regenerative Medicine. Science and Technology of Advanced Materials, 11: 014102 (2010).
  22. H Tian, S Bharadwaj, Y Liu, PX Ma, A Atala and Y Zhang. Differentiation of Human Bone Marrow Mesenchymal Stem Cells into Bladder Cells: Potential for Urological Tissue Engineering, Tissue Engineering, Part A, 16(5): 1769-1779 (2010).
  23. LA Smith, X Liu, J Hu, and PX Ma. The Enhancement of Human Embryonic Stem Cell Osteogenic Differentiation with Nano-fibrous Scaffolding. Biomaterials, 31(21):5526-5535 (2010).
  24. J Wang, X Liu, X Jin, H Ma, J Hu, L Ni and PX Ma.  The odontogenic differentiation of human dental pulp stem cells on nanofibrous poly(l-lactic acid) scaffolds in vitro and in vivo. Acta Biomaterialia, 6:3856-3863 (2010).
  25. K Feng, H Sun, MA Bradley, EJ Dupler, WV. Giannobile, and PX Ma. Novel Antibacterial Nanofibrous PLLA Scaffolds. Journal of Controlled Release. 146: 363-369 (2010).
  26. H Ma, J Hu and PX Ma, Polymer scaffolds for small-diameter vascular tissue engineering. Advanced Functional Materials, 20(17), 2833 (2010).
  27. J Hu, X Sun, H Ma, CQ Xie, YE Chen, PX Ma. Porous nano-fibrous PLLA scaffolds for vascular tissue engineering. Biomaterials. 31:7971-7977  (2010).
  28. J Hu, L Smith, K Feng, X Liu, H Sun and PX Ma. Response of Human Embryonic Stem Cells Derived Mesenchymal Stem Cells to Osteogenic Factors and Architectures of Materials during in vitro Osteogenesis, Tissue Engineering: Part A 16(11):3507-3514 (2010).
  29. JX Zhang, K Ellsworth, PX Ma. Hydrophobic pharmaceuticals mediated self-assembly of b-cyclodextrin containing hydrophilic copolymers: Novel chemical responsive nano-vehicles for drug delivery. Journal of Controlled Release, 145(2):116-123 (2010).
  30. CL He, GY Xiao, XB Jin, CH Sun and PX Ma, Electrodeposition on nanofibrous polymer scaffolds: Rapid mineralization, tunable calcium phosphate composition and topography. Advanced Functional Materials, 20(20):3568-3576 (2010).
  31. JX Zhang and PX Ma, Host-guest interactions mediated nano-assemblies using cyclodextrin-containing hydrophilic polymers and their biomedical applications. Nano Today. 5:337-350 (2010).
  32. X Liu, X Jin and PX Ma. Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair. Nature Materials, 10(5):398-406 (2011).
  33. E. Török*, M. Lütgehetmann*, J. Bierwolf, S. Melbeck, J. Düllmann, M. Burda, M. Dandri, J. Petersen, B. Nashan, P.X. Ma, J.-M. Pollok. Primary human hepatocytes on biodegradable PLLA-matrices - a promising model for improving transplantation efficiency using tissue engineering. Liver Transplantation, 17:104-114 (2011).
  34. J Bierwolf, M Lütgehetmann, K Feng, J Erbes, S Deichmann, E Toronyi, C Stieglitz, B Nashan, PX Ma, JM Pollok. Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research. Biotechnology and Bioengineering, 108(1):141-150 (2011).
  35. J Hu and PX Ma. Nanofibrous Tissue Engineering Scaffolds Capable of Growth Factor Delivery. Pharmaceutical Research, 28(6):1273-1281 (2011).
  36. C Xie, J Hu, H Ma, J Chang, LJ Chang, YE Chen, PX Ma. Three-dimensional growth of iPS cell-derived smooth muscle cells on nanofibrous scaffolds, Biomaterials, 32: 4369-4375 (2011).
  37. JM Holzwarth and PX Ma. 3D nanofibrous scaffolds for tissue engineering, Journal of Materials Chemistry, Feature Article, 21(28), 10243-10251 (2011).
  38. J Wang, H Ma, X Jin, J Hu, X Liu, L Ni and PX Ma. The effect of scaffold architecture on odontogenic differentiation of human dental pulp stem cells, Biomaterials, 32(31):7822-7830 (2011).
  39. JX Zhang and PX Ma. Core-shell structured nanoassemblies based on β-cyclodextrin containing block copolymer and poly(β-benzyl L-aspartate) via host-guest complexation. Polymer, 52(21):4928-4937 (2011).
  40. JM Holzwarth and PX Ma. Biomimetic nanofibrous scaffolds for bone tissue engineering. Biomaterials, 32: 9622-9629 (2011)
  41. WV Giannobile, SJ Hollister and PX Ma. Future Perspectives using Growth Factors for Periodontal Bioengineering, Clinical Advances in Periodontics, 1(2):88-94 (2011).
  42. G Feng, X Jin, J Hu, H Ma, MJ Gupte, H Liu, PX Ma. Effects of Hypoxia and Scaffold Architecture on Rabbit Mesenchymal Stem Cell Differentiation towards a Nucleus Pulposus-like Phenotype, Biomaterials, 32:8182-8189 (2011).
  43. LA Smith and PX Ma, Chapter 7. Effect of Nanofibrous Scaffolding on Stem Cell Differentiation and Tissue Formation. in: D Shum-Tim & S Prakash (Ed), Stem Cell Bioengineering and Tissue Microenvironment, World Scientific Publishing Co, pp205-217 (2011).
  44. IO Smith and PX Ma. Scaffolds in Tissue Engineering: Biomimetic Materials, In: N. Pallua and C. Suscheck (Editors) Tissue Engineering: From Lab to Clinic, Springer, New York, NY.  Pp-31-40 (2011).
  45. J. Hu, X. Liu, and P.X. Ma, Biomineralization and Bone Regeneration. Chapter 40, In: Anthony Atala, Robert Lanza, James A. Thomson, and Robert M. Nerem (Editors) Principles of Regenerative Medicine. 2nd Edition, ELSEVIER, Pp 733- 745 (2011).
  46. IO Smith and PX Ma. Biomimetic Scaffolds in Tissue Engineering, In: JJ Yoo & A Atala (Editors) The Handbook of Enabling Technologies for Regenerative Medicine, Artech House, Inc. Norwood, Massachusetts, in press (2011).
  47. LA Smith and PX Ma. Computer-designed nano-fibrous scaffolds, In: In: Michael Liebschner (Editor), Computer-Aided Tissue Engineering, Springer, New York, NY, Methods in Molecular Biology, Vol. 868, 125-134 (2012).
  48. MJ Gupte and PX Ma. Nanofibrous Scaffolds for Dental and Craniofacial Applications, Journal of Dental Research, invited review, 91(30): 227 – 234 (2012).
  49. Z Zhang, J Hu, and PX Ma. Nanofiber-based delivery of bioactive agents and stem cells to bone sites. Advanced Drug Delivery Reviews, 64(12): 1129-1141 (2012).
  50. JX Zhang, K Ellsworth, PX Ma. Synthesis of β-Cyclodextrin Containing Copolymer via ‘Click’ Chemistry and Its Self-Assembly in the Presence of Guest Compounds. Macromolecular Rapid Communications, 33(8): 664-671 (2012).
  51. X Liu, J Holzwarth, and PX Ma. Functionalized synthetic biodegradable polymer scaffolds for tissue engineering. Macromolecular Bioscience, 12(7): 911-919 (2012).
  52. X Chatzistavrou, S Papagerakis, PX Ma and P Papagerakis. Innovative Approaches to Regenerate Enamel and Dentin. International Journal of Dentistry, Article ID 856470, 5 pages (2012).
  53. C Sun, X Jin, JM Holzwarth, X Liu, J Hu, MJ Gupte, Y Zhao and PX Ma. Development of channeled nanofibrous scaffolds for engineering oriented tissue bundles. Macromolecular Bioscience, 12(6): 761-769 (2012).
  54. C Xie, Y Guo, T Zhu, J Zhang, PX Ma, YE Chen. Yap1 regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin. Journal of Biological Chemistry, 287(18): 14598-14605 (2012).
  55. J Hu, C Xie, H Ma, B Yang, PX Ma*, YE Chen*. Construction of Vascular Tissues with Macro-porous Nano-fibrous Scaffolds and Smooth Muscle Cells Enriched from Differentiated Embryonic Stem Cells. PLoS ONE, 7(4): e35580 (2012).
  56. G Feng, Z Zhang, X Jin, J Hu, MJ Gupte, JM Holzwarth, and PX Ma. Regenerating nucleus pulposus of the intervertebral disc using biodegradable nanofibrous polymer scaffolds. Tissue Engineering: Part A, 18(21&22), 2231-2238 (2012).
  57. YG Ko and PX Ma. Growth of oriented p-aminobenzoic acid crystals by directional freezing. CrystEngComm, 14(23), 7891-7894 (2012).
  58. Z Zhang, M Gupte, and PX Ma. Biomaterials and Stem Cells for Tissue Engineering. Expert Opinion on Biological Therapy, 13(4):527-540 (2013).
  59. RJ Kane and PX Ma. Biomimetic Nanofibrous Scaffolds for Bone Tissue Engineering Applications, in:  M Ramalingam, X Wang, G Chen, PX Ma, FZ Cui (Ed). Biomimetics: Advancing Nanobiomaterials and Tissue Engineering, John Wiley-Scrivener Publishing, PP69-89 (2013).
  60. G Feng, L Li, H Liu, Y Song, F Huang, C Tu, B Shen, Q Gong, T Li, L Liu, J. Zeng, Q Kong, M Yi, M Gupte, PX Ma* and F Pei*. Hypoxia differentially regulates human nucleus pulposus and annualus fibrosus cell extracellular matrix production in 3D scaffolds. Osteoarthritis and Cartilage, 21: 582-588 (2013).
  61. JX Zhang and PX Ma. Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective. Advanced Drug Delivery Reviews, 65:1215-1233 (2013).
  62. C He, X Jin and PX Ma. Calcium phosphate deposition rate, structure and osteoconductivity on electrospun poly(l-lactic acid) matrix using electrodeposition or simulated body fluid incubation. Acta Biomaterialia, 10(1): 419-427 (2014) (2013).
  63. RJ Kane and PX Ma. Mimicking the nanostructure of bone matrix to regenerate bone. Materials Today, 16(11): 418-423 (2013).
  64. H Xu, JM Holzwarth, Y Yan, P Xu, H Zheng, Y Yin, S Li, and PX Ma. Conductive PPY/PDLLA conduit for peripheral nerve regeneration. Biomaterials, 35:225-235 (2014).
  65. Z Zhang, JM Holzwarth and PX Ma, Nanofibrous Polymer Scaffolds with Designed Pore Structure, in: PX Ma (Ed) Biomaterials and Regenerative Medicine, Cambridge University Press, in press (2014).
  66. K Feng, J Hu and PX Ma. Growth Factor Delivery Scaffolds, in: PX Ma (Ed) Biomaterials and Regenerative Medicine, Cambridge University Press, in press (2014).
  67. IO Smith, MJ Gupte and PX Ma. Polymer/Ceramic Composite Scaffolds for Regeneration, in: PX Ma (Ed) Biomaterials and Regenerative Medicine, Cambridge University Press, in press (2014).
  68. J Wang, X Jin, PX Ma. Dentin-pulp tissue engineering and regeneration, in: PX Ma (Ed) Biomaterials and Regenerative Medicine, Cambridge University Press, in press (2014).
  69. G Wei and PX Ma. Chapter 2: Polymeric Biomaterials. In: A Boccaccini and PX Ma (Ed) Tissue Engineering Using Ceramics and Polymers, 2nd Edition, Woodhead Publishing Ltd, in press (2014).
  70. M Dang, JM Shin and PX Ma. Synthetic Biomimetic Porous Polymer Scaffolds for Bone Regeneration, in: CT Laurencin and J Tao (Eds) Synthetic Biomimetic Polymer Scaffolds for Bone Regeneration, ASTM International, in press (2014).
  71. B Guo and PX Ma. Synthetic biodegradable functional polymers for tissue engineering – A brief review. SCIENCE CHINA Chemistry, in press (2014).
  72. L Zhang, L Wang, B Guo, and PX Ma. Cytocompatible injectable carboxymethyl chitosan/N-isopropylacrylamide hydrogels for localized drug delivery. Carbohydrate Polymers, in press (2014).
  73. L Li, J Ge, B Guo, and PX Ma. In situ forming biodegradable electroactive hydrogels. Polymer Chemistry, in press (2014).
  74. X Ma, J Ge, Y Li, B Guo and PX Ma. Nanofibrous electroactive scaffolds from chitosan-grafted-aniline tetramer by electrospining for tissue engineering. RSC Advances, in press (2014).