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Biologic and Materials Sciences and Division of Prosthodontics

Mishina Lab

 

Dr. Mishina’s laboratory is interested in functions of BMP signaling during bone development/remodeling and craniofacial development. They recently developed several mouse lines to conditionally decrease or increase levels of BMP signaling using a Cre-loxP system. When BMP signaling through BMP type IA receptor (BMPRIA) was specifically knocked out in osteoblasts, bone mass was increased, unlike what was predicted, by decrease of osteoclastogenesis. Molecular analyses revealed that BMP signaling in osteoblasts positively regulates expression of sclerostin, an inhibitor for Wnt signaling, in turn, negatively regulates Wnt signaling, subsequently influences OPG/RANKL pathway to support osteoclast functions. This would be an interesting model to understand pathogenesis of bone mass related diseases including osteoporosis and Sclerosis. 
When BMP signaling through BMPRIA was specifically activated in neural crest derived tissues, premature fusion of frontal suture was observed that lead to a morphological abnormality known as craniosinostosis. This phenotype was rescued in a heterozygous null background of Bmpr1a suggesting that amount of BMP signaling needs to be tightly regulated for normal development.Dr. Mishina’s laboratory is interested in functions of BMP signaling during bone development/remodeling and craniofacial development. They recently developed several mouse lines to conditionally decrease or increase levels of BMP signaling using a Cre-loxP system. When BMP signaling through BMP type IA receptor (BMPRIA) was specifically knocked out in osteoblasts, bone mass was increased, unlike what was predicted, by decrease of osteoclastogenesis. Molecular analyses revealed that BMP signaling in osteoblasts positively regulates expression of sclerostin, an inhibitor for Wnt signaling, in turn, negatively regulates Wnt signaling, subsequently influences OPG/RANKL pathway to support osteoclast functions. This would be an interesting model to understand pathogenesis of bone mass related diseases including osteoporosis and Sclerosis. 
When BMP signaling through BMPRIA was specifically activated in neural crest derived tissues, premature fusion of frontal suture was observed that lead to a morphological abnormality known as craniosinostosis. This phenotype was rescued in a heterozygous null background of Bmpr1a suggesting that amount of BMP signaling needs to be tightly regulated for normal development.

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